Publication

Vitamin D deficiency and course of frailty in a depressed older population

van den Berg, K. S., Arts, M. H. L., Collard, R. M., van den Brink, R. H. S., Comijs, H. C., Marijnissen, R. M. & Oude Voshaar, R. C., 2-Jan-2020, In : AGING & MENTAL HEALTH. 24, 1, p. 49-55 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van den Berg, K. S., Arts, M. H. L., Collard, R. M., van den Brink, R. H. S., Comijs, H. C., Marijnissen, R. M., & Oude Voshaar, R. C. (2020). Vitamin D deficiency and course of frailty in a depressed older population. AGING & MENTAL HEALTH, 24(1), 49-55. https://doi.org/10.1080/13607863.2018.1515885

Author

van den Berg, Karen S ; Arts, Matheus H L ; Collard, Rose M ; van den Brink, Rob H S ; Comijs, Hannie C ; Marijnissen, Radboud M ; Oude Voshaar, Richard C. / Vitamin D deficiency and course of frailty in a depressed older population. In: AGING & MENTAL HEALTH. 2020 ; Vol. 24, No. 1. pp. 49-55.

Harvard

van den Berg, KS, Arts, MHL, Collard, RM, van den Brink, RHS, Comijs, HC, Marijnissen, RM & Oude Voshaar, RC 2020, 'Vitamin D deficiency and course of frailty in a depressed older population', AGING & MENTAL HEALTH, vol. 24, no. 1, pp. 49-55. https://doi.org/10.1080/13607863.2018.1515885

Standard

Vitamin D deficiency and course of frailty in a depressed older population. / van den Berg, Karen S; Arts, Matheus H L; Collard, Rose M; van den Brink, Rob H S; Comijs, Hannie C; Marijnissen, Radboud M; Oude Voshaar, Richard C.

In: AGING & MENTAL HEALTH, Vol. 24, No. 1, 02.01.2020, p. 49-55.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van den Berg KS, Arts MHL, Collard RM, van den Brink RHS, Comijs HC, Marijnissen RM et al. Vitamin D deficiency and course of frailty in a depressed older population. AGING & MENTAL HEALTH. 2020 Jan 2;24(1):49-55. https://doi.org/10.1080/13607863.2018.1515885


BibTeX

@article{eafdfbf01c1347fb9494913e0b824fc7,
title = "Vitamin D deficiency and course of frailty in a depressed older population",
abstract = "Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95{\%}-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95{\%}-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95{\%}-CI 1.23 - 6.49], p=.015). Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.",
keywords = "Vitamin D, frailty, depression, prevalence, course, old age, 25-HYDROXYVITAMIN D LEVELS, LATE-LIFE, ASSOCIATION, ADULTS, MORTALITY, MEN, RECEPTOR, HEALTH",
author = "{van den Berg}, {Karen S} and Arts, {Matheus H L} and Collard, {Rose M} and {van den Brink}, {Rob H S} and Comijs, {Hannie C} and Marijnissen, {Radboud M} and {Oude Voshaar}, {Richard C}",
year = "2020",
month = "1",
day = "2",
doi = "10.1080/13607863.2018.1515885",
language = "English",
volume = "24",
pages = "49--55",
journal = "AGING & MENTAL HEALTH",
issn = "1360-7863",
publisher = "ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD",
number = "1",

}

RIS

TY - JOUR

T1 - Vitamin D deficiency and course of frailty in a depressed older population

AU - van den Berg, Karen S

AU - Arts, Matheus H L

AU - Collard, Rose M

AU - van den Brink, Rob H S

AU - Comijs, Hannie C

AU - Marijnissen, Radboud M

AU - Oude Voshaar, Richard C

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015). Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

AB - Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015). Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

KW - Vitamin D

KW - frailty

KW - depression

KW - prevalence

KW - course

KW - old age

KW - 25-HYDROXYVITAMIN D LEVELS

KW - LATE-LIFE

KW - ASSOCIATION

KW - ADULTS

KW - MORTALITY

KW - MEN

KW - RECEPTOR

KW - HEALTH

U2 - 10.1080/13607863.2018.1515885

DO - 10.1080/13607863.2018.1515885

M3 - Article

VL - 24

SP - 49

EP - 55

JO - AGING & MENTAL HEALTH

JF - AGING & MENTAL HEALTH

SN - 1360-7863

IS - 1

ER -

ID: 65760291