Publication

Vitamin D deficiency and course of frailty in a depressed older population

van den Berg, K. S., Arts, M. H. L., Collard, R. M., van den Brink, R. H. S., Comijs, H. C., Marijnissen, R. M. & Oude Voshaar, R. C., 15-Nov-2018, In : Aging and Mental Health. p. 1-7 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van den Berg, K. S., Arts, M. H. L., Collard, R. M., van den Brink, R. H. S., Comijs, H. C., Marijnissen, R. M., & Oude Voshaar, R. C. (2018). Vitamin D deficiency and course of frailty in a depressed older population. Aging and Mental Health, 1-7. https://doi.org/10.1080/13607863.2018.1515885

Author

van den Berg, Karen S ; Arts, Matheus H L ; Collard, Rose M ; van den Brink, Rob H S ; Comijs, Hannie C ; Marijnissen, Radboud M ; Oude Voshaar, Richard C. / Vitamin D deficiency and course of frailty in a depressed older population. In: Aging and Mental Health. 2018 ; pp. 1-7.

Harvard

van den Berg, KS, Arts, MHL, Collard, RM, van den Brink, RHS, Comijs, HC, Marijnissen, RM & Oude Voshaar, RC 2018, 'Vitamin D deficiency and course of frailty in a depressed older population', Aging and Mental Health, pp. 1-7. https://doi.org/10.1080/13607863.2018.1515885

Standard

Vitamin D deficiency and course of frailty in a depressed older population. / van den Berg, Karen S; Arts, Matheus H L; Collard, Rose M; van den Brink, Rob H S; Comijs, Hannie C; Marijnissen, Radboud M; Oude Voshaar, Richard C.

In: Aging and Mental Health, 15.11.2018, p. 1-7.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van den Berg KS, Arts MHL, Collard RM, van den Brink RHS, Comijs HC, Marijnissen RM et al. Vitamin D deficiency and course of frailty in a depressed older population. Aging and Mental Health. 2018 Nov 15;1-7. https://doi.org/10.1080/13607863.2018.1515885


BibTeX

@article{eafdfbf01c1347fb9494913e0b824fc7,
title = "Vitamin D deficiency and course of frailty in a depressed older population",
abstract = "OBJECTIVE: To study the association between vitamin D levels and frailty, its components and course in a depressed sample.METHODS: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates.RESULTS: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95{\%}-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95{\%}-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95{\%}-CI 1.23 - 6.49], p=.015).CONCLUSIONS: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.",
author = "{van den Berg}, {Karen S} and Arts, {Matheus H L} and Collard, {Rose M} and {van den Brink}, {Rob H S} and Comijs, {Hannie C} and Marijnissen, {Radboud M} and {Oude Voshaar}, {Richard C}",
year = "2018",
month = "11",
day = "15",
doi = "10.1080/13607863.2018.1515885",
language = "English",
pages = "1--7",
journal = "Aging and Mental Health",
issn = "1364-6915",

}

RIS

TY - JOUR

T1 - Vitamin D deficiency and course of frailty in a depressed older population

AU - van den Berg, Karen S

AU - Arts, Matheus H L

AU - Collard, Rose M

AU - van den Brink, Rob H S

AU - Comijs, Hannie C

AU - Marijnissen, Radboud M

AU - Oude Voshaar, Richard C

PY - 2018/11/15

Y1 - 2018/11/15

N2 - OBJECTIVE: To study the association between vitamin D levels and frailty, its components and course in a depressed sample.METHODS: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates.RESULTS: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015).CONCLUSIONS: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

AB - OBJECTIVE: To study the association between vitamin D levels and frailty, its components and course in a depressed sample.METHODS: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates.RESULTS: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015).CONCLUSIONS: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

U2 - 10.1080/13607863.2018.1515885

DO - 10.1080/13607863.2018.1515885

M3 - Article

SP - 1

EP - 7

JO - Aging and Mental Health

JF - Aging and Mental Health

SN - 1364-6915

ER -

ID: 65760291