Vitamin D deficiency and course of frailty in a depressed older population

van den Berg, K. S., Arts, M. H. L., Collard, R. M., van den Brink, R. H. S., Comijs, H. C., Marijnissen, R. M. & Oude Voshaar, R. C., 2-Jan-2020, In : AGING & MENTAL HEALTH. 24, 1, p. 49-55 7 p.

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Objective: To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Methods: Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Results: Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], p = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], p=.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], p=.015). Conclusions: In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
Issue number1
Early online date15-Nov-2018
Publication statusPublished - 2-Jan-2020


  • Vitamin D, frailty, depression, prevalence, course, old age, 25-HYDROXYVITAMIN D LEVELS, LATE-LIFE, ASSOCIATION, ADULTS, MORTALITY, MEN, RECEPTOR, HEALTH

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