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Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

Emblem, K. E., Mouridsen, K., Bjornerud, A., Farrar, C. T., Jennings, D., Borra, R. J. H., Wen, P. Y., Ivy, P., Batchelor, T. T., Rosen, B. R., Jain, R. K. & Sorensen, A. G., Sep-2013, In : Nature Medicine. 19, 9, p. 1178-1183 6 p.

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  • Vessel architectural imaging identifies cancer patient responders to anti-angiogenic therapy

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DOI

  • Kyrre E. Emblem
  • Kim Mouridsen
  • Atle Bjornerud
  • Christian T. Farrar
  • Dominique Jennings
  • Ronald J. H. Borra
  • Patrick Y. Wen
  • Percy Ivy
  • Tracy T. Batchelor
  • Bruce R. Rosen
  • Rakesh K. Jain
  • A. Gregory Sorensen

Measurement of vessel caliber by magnetic resonance imaging (MRI) is a valuable technique for in vivo monitoring of hemodynamic status and vascular development, especially in the brain. Here, we introduce a new paradigm in MRI termed vessel architectural imaging (VAI) that exploits an overlooked temporal shift in the magnetic resonance signal, forming the basis for vessel caliber estimation, and show how this phenomenon can reveal new information on vessel type and function not assessed by any other noninvasive imaging technique. We also show how this biomarker can provide new biological insights into the treatment of patients with cancer. As an example, we demonstrate using VAI that anti-angiogenic therapy can improve microcirculation and oxygen saturation and reduce vessel calibers in patients with recurrent glioblastomas and, more crucially, that patients with these responses have prolonged survival. Thus, VAI has the potential to identify patients who would benefit from therapies.

Original languageEnglish
Pages (from-to)1178-1183
Number of pages6
JournalNature Medicine
Volume19
Issue number9
Publication statusPublished - Sep-2013

    Keywords

  • ENDOTHELIAL GROWTH-FACTOR, MAGNETIC-SUSCEPTIBILITY, ANTIANGIOGENIC THERAPY, GLIOBLASTOMA PATIENTS, TUMOR ANGIOGENESIS, KINASE INHIBITOR, MR CONTRAST, VASCULATURE, MICROCIRCULATION, MECHANISMS

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