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VERTOS II: Percutaneous vertebroplasty versus conservative therapy in patients with painful osteoporotic vertebral compression fractures; rationale, objectives and design of a multicenter randomized controlled trial

Klazen, C., Verhaar, H., Lampmann, L., Juttmann, J., Blonk, M., Jansen, F., Tielbeek, A., Schoemaker, M., Buskens, E., van der Graaf, Y., Janssens, X., Fransen, H., van Everdingen, K., Muller, A., Mali, W. & Lohle, P., 31-Oct-2007, In : TRIALS. 8, 5 p., 33.

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DOI

  • C. Klazen
  • H. Verhaar
  • L. Lampmann
  • J. Juttmann
  • M. Blonk
  • F. Jansen
  • A. Tielbeek
  • M. Schoemaker
  • E. Buskens
  • Y. van der Graaf
  • X. Janssens
  • H. Fransen
  • K. van Everdingen
  • A. Muller
  • W. Mali
  • P. Lohle

Background: The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy. Percutaneous vertebroplasty (PV), a minimally invasive technique, is gaining popularity as a new treatment option. Many prospective and retrospective studies have reported on the effectiveness and safety of PV, but no large randomized controlled trial (RCT) has been published.

Objective: To estimate cost-effectiveness of PV compared to conservative therapy in terms of: pain reduction, quality of life, complications, secondary fractures and mortality.

Materials and methods: The VERTOS II study is designed as a prospective, multicenter RCT. Patients with a painful VCF with bone edema on MR imaging, local back pain for 6 weeks or less, osteopenia and aged 50 years or older, after obtaining informed consent are included and randomized for PV or conservative therapy. In total 200 patients will be enrolled. Follow-up is at regular intervals during a 1-year period with standard questionnaires, addressing: clinical symptoms, pain medication, Visual Analogue Scale (VAS) score, quality of life and cost-effectiveness. Secondary fractures, necessary additional therapies and complications are recorded. Conclusion: The VERTOS II study is the first methodologically sound RCT designed to assess the cost-effectiveness of PV compared to conservative therapy in patients with an acute osteoporotic VCF.

Original languageEnglish
Article number33
Number of pages5
JournalTRIALS
Volume8
Publication statusPublished - 31-Oct-2007

    Keywords

  • QUALITY-OF-LIFE, LOW-BACK-PAIN, FOLLOW-UP, NATURAL-HISTORY, IMPROVEMENT, OUTCOMES

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