Ventricular Tachyarrhythmia Detection by Implantable Loop Recording in Patients with Heart Failure and Preserved Ejection Fraction: The VIP-HF studyvan Veldhuisen, D. J., van Woerden, G., Gorter, T. M., van Empel, V. P. M., Manintveld, O. C., Tieleman, R. G., Maass, A. H., Vernooy, K., Westenbrink, B. D., van Gelder, I. C. & Rienstra, M., 21-Aug-2020, In : European Journal of Heart Failure. 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
AIMS: The primary aim of the VIP-HF study was to examine the incidence of sustained ventricular tachyarrhythmias (VT) in heart failure (HF) with mid-range or preserved left ventricular ejection fraction (HFmrEF/HFpEF). Secondary aims were to examine the incidence of non-sustained VTs, bradyarrhythmias, HF hospitalizations and mortality.
METHODS AND RESULTS: This was an investigator-initiated, prospective, multicentre, observational study of patients with HF and LVEF >40%. Patients underwent extensive phenotyping, after which an implantable loop recorder was implanted. We enrolled 113 of the planned 250 patients; mean age 73±8 years, 51% women, 54/46% NYHA class II/III, median NTproBNP 1367[710-2452] pg/ml and mean LVEF 54±6%, 75% had LVEF>50%. Eighteen percent had non-sustained VTs and 38% had atrial fibrillation on Holter. During a median follow-up of 657 (219-748) days, the primary endpoint of sustained VT was observed in one patient. The incidence of the primary endpoint was 0.6 (95% confidence interval [CI] 0.2-3.5) per 100 personyears. The incidence of the secondary endpoint of non-sustained VT was 11.5 (7.1-18.7) per 100 personyears. Five patients developed bradyarrhythmias (3.2[1.4-7.5] per 100 personyears), 3 were implanted with a pacemaker. In total, 23 patients (20%) were hospitalized for HF (16.3[10.9-24.4] per 100 personyears). Fourteen patients (12%) died (8.7[5.2-14.7] per 100 personyears); 10 due to cardiovascular causes, and four sudden deaths, one with ILR-confirmed bradyarrhythmias as terminal event, 3 others undetermined.
CONCLUSION: Despite the lower than expected number of included patients, the incidence of sustained VT in HFmrEF/HFpEF was low. Clinically relevant bradyarrhyhmias were more often observed than expected.
|Number of pages||7|
|Journal||European Journal of Heart Failure|
|Early online date||19-Jul-2020|
|Publication status||Published - 21-Aug-2020|