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Various distinctive cytogenetic abnormalities in patients with acute myeloid leukaemia aged 60 years and older express adverse prognostic value: results from a prospective clinical trial

van der Holt, B., Breems, D. A., Beverloo, H. B., van den Berg, E., Burnett, A. K., Sonneveld, P. & Lowenberg, B., Jan-2007, In : British Journal of Haematology. 136, 1, p. 96-105 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

  • Bronno van der Holt
  • Dimitri A. Breems
  • H. Berna Beverloo
  • Eva van den Berg
  • Alan K. Burnett
  • Pieter Sonneveld
  • Bob Lowenberg

Diagnostic cytogenetic abnormalities are considered important prognostic factors in patients with acute myeloid leukaemia (AML). However, the prognostic assessments have mainly been derived from patients with AML aged <60 years. Two recent studies of AML patients of 60 years and older proposed prognostic classifications with distinct discrepancies. To further study the prognostic value of cytogenetic abnormalities in this patient population, we have evaluated cytogenctic abnormalities in a series of 293 untreated patients with AML aged 60 years and older, included in a randomised phase 3 trial, also in relation to patient characteristics and clinical outcome. The most frequently observed cytogenetic abnormality was trisomy 8 (+8), in 31 (11%) patients. Abnormalities, such as -5, 5q-, abn(17p) and abn(17q), were almost exclusively present in complex karyotypes. A relatively favourable outcome was only observed in five patients with core-binding factor abnormalities t(8;21) and inv(16)/del(16)/ t(16;16). However, most of the other evaluated cytogenetic abnormalities, such as 5q-, -7, +8, abn(17p), abn(17q), and complex aberrations expressed a more adverse prognosis when compared with patients with AML aged 60 years and older with a normal karyotype. Large studies to confirm the prognosis of individual cytogenetic aberrations are warranted.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
JournalBritish Journal of Haematology
Volume136
Issue number1
Publication statusPublished - Jan-2007

    Keywords

  • acute myeloid leukaemia, cytogenetics, elderly patients, prognosis, survival, ACUTE MYELOGENOUS LEUKEMIA, COLONY-STIMULATING FACTOR, 4TH INTERNATIONAL WORKSHOP, COOPERATIVE-ONCOLOGY-GROUP, COUNCIL AML11 TRIAL, LONG-TERM SURVIVAL, GROUP-B 8461, ELDERLY-PATIENTS, FOLLOW-UP, TRISOMY-8

ID: 4525146