Publication

Vanin 1: Its Physiological Function and Role in Diseases

Bartucci, R., Salvati, A., Olinga, P. & Boersma, Y. L., 9-Aug-2019, In : International Journal of Molecular Sciences. 20, 16, 15 p., 3891.

Research output: Contribution to journalReview articleAcademicpeer-review

The enzyme vascular non-inflammatory molecule-1 (vanin 1) is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney. Its major function is related to its pantetheinase activity; vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Indeed, its physiological role seems strictly related to coenzyme A metabolism, lipid metabolism, and energy production. In recent years, many studies have elucidated the role of vanin 1 under physiological conditions in relation to oxidative stress and inflammation. Vanin's enzymatic activity was found to be of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. In this review, we discuss the role of vanin 1 in the liver, kidney, intestine, and lung under physiological as well as pathophysiological conditions. Thus, we provide a more complete understanding and overview of its complex function and contribution to some specific pathologies.

Original languageEnglish
Article number3891
Number of pages15
JournalInternational Journal of Molecular Sciences
Volume20
Issue number16
Publication statusPublished - 9-Aug-2019

    Keywords

  • Vanin 1, oxidative stress, PPAR-alpha, PPAR-gamma, urinary biomarker, pro-inflammatory role, protective role, NONALCOHOLIC FATTY LIVER, GENE-EXPRESSION, PANTOTHENIC-ACID, NATURAL-HISTORY, COENZYME-A, PPAR-ALPHA, MOUSE, PANTETHEINASE, CYSTEAMINE, PROTEIN

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