Publication

Using Small-Angle Scattering and Contrast Matching to Understand Molecular Packing in Low Molecular Weight Gels

Draper, E. R., Dietrich, B., McAuluy, K., Brasnett, C., Abdizadeh, H., Patmanidis, I., Marrink, S., Su, H., Cui, H., Schweins, R., Seddon, A. & Adams, D. J., 4-Mar-2020, In : Matter. 2, 3, p. 764-778 15 p.

Research output: Contribution to journalArticleAcademicpeer-review

It is difficult to determine exactly the molecular packing in the aggregates in low molecular weight gels. Attempts to understand the packing have been made us- ing X-ray diffraction, but there are complications with drying and questions as to whether the crystal structures represent the packing in the gel phase. Here, we exploit contrast matching in small-angle neutron scattering experiments. By preparing selectively deuterated analogs of the same molecule, the scattering from that section of the molecule decreases compared with the hydrogenated molecule. We examine packing in the pre-gelled solutions at high pH and in the gels at low pH. The data from the final gels show a lack of specific order in the aggregates that form the gel matrix. The packing in these systems is not well ordered in the gel state and so implies that it is likely that current models and cartoons are not correct.
Original languageEnglish
Pages (from-to)764-778
Number of pages15
JournalMatter
Volume2
Issue number3
Early online date29-Jan-2020
Publication statusPublished - 4-Mar-2020

    Keywords

  • SUPRAMOLECULAR HYDROGEL, FMOC-DIPHENYLALANINE, SELF, PEPTIDES, GELATORS, GELATION, TRANSITION, SOLVENT, DESIGN

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