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Urinary Excretion of Sulfur Metabolites and Risk of Cardiovascular Events and All-Cause Mortality in the General Population

van den Born, J., Frenay, A-R., Koning, A. M., Bachtler, M., Riphagen, I., Minovic, I., Feelisch, M., Dekker, M., Bulthuis, M., Gansevoort, R., Hillebrands, J-L., Pasch, A., Bakker, S. & van Goor, H., 23-Apr-2019, In : Antioxidants & Redox Signaling. 30, 17, p. 1999-2010 12 p.

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  • Is excretion of sulfur metabolites related to risk of cardiovascular events or mortality in the general population?

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DOI

Aims: Thiosulfate and sulfate are metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular (CV) protective properties. Urinary thiosulfate excretion and sulfate excretion are associated with favorable disease outcome in high-risk patient groups. We investigated the relationship between urinary excretion of sulfur metabolites, and risk of CV events and all-cause mortality in the general population.

Results: Subjects (n = 6839) of the Prevention of Renal and Vascular End-stage Disease (PREVEND) study were followed prospectively. At baseline, 24-h urinary excretion of thiosulfate and sulfate was determined. Median urinary thiosulfate and sulfate excretion values were 1.27 (interquartile range [IQR] 0.89-2.37) mol/24h and 15.7 (IQR 12.0-20.3) mmol/24h, respectively. Neither thiosulfate nor sulfate excretion showed an independent association with risk of CV events. Sulfate, but not thiosulfate, was inversely associated with risk of all-cause mortality, independent of potential confounders (hazard ratio 0.73 [95% confidence interval 0.63-0.84], p

Innovation: The strong association between sulfate excretion and mortality in the general population emphasizes the (patho)physiological importance of sulfate or its precursor H2S.

Conclusion: We hypothesize that urinary sulfate excretion, which is inversely associated with all-cause mortality in the general population, holds clinical relevance as a beneficial modulator in health and disease.

Original languageEnglish
Pages (from-to)1999-2010
Number of pages12
JournalAntioxidants & Redox Signaling
Volume30
Issue number17
Publication statusPublished - 23-Apr-2019

    Keywords

  • epidemiology, cardiovascular events, mortality, sulfate, thiosulfate, hydrogen sulfide, METHIONINE-SUPPLEMENTED DIET, GLOMERULAR-FILTRATION-RATE, HYDROGEN-SULFIDE, BLOOD-PRESSURE, AMINO-ACIDS, HYPERTENSIVE-RATS, HEART-FAILURE, RENAL-DISEASE, SULFATE, THIOSULFATE

ID: 62228711