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Urinary Ethyl Glucuronide Can Be Used as a Biomarker of Habitual Alcohol Consumption in the General Population

van de Luitgaarden, I. A. T., Beulens, J. W. J., Schrieks, I. C., Kieneker, L. M., Touw, D. J., van Ballegooijen, A. J., van Oort, S., Grobbee, D. E. & Bakker, S. J. L., Dec-2019, In : Journal of Nutrition. 149, 12, p. 2199-2205 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Alcohol consumption is a frequently studied risk factor for chronic diseases, but many studies are hampered by self-report of alcohol consumption. The urinary metabolite ethyl glucuronide (EtG), reflecting alcohol consumption during the past 72 h, is a promising objective marker, but population data are lacking.

Objective: The objective of this study was to assess the reliability of EtG as a marker for habitual alcohol consumption compared with self-report and other biomarkers in the general population.

Methods: Among 6211 participants in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, EtG concentrations were measured in 24-h urine samples. EtG was considered positive when concentrations were >= 100 ng/mL. Habitual alcohol consumption was self-reported by questionnaire (categories: no/almost never, 1-4 units per month, 2-7 units per week, 1-3 units per day or >= 4 units per day). Plasma HDL cholesterol concentration, erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) were determined as indirect biomarkers of alcohol consumption. Sensitivity, specificity, positive and negative predictive value, and proportions of agreement between reported consumption and EtG were calculated. To test the agreement of EtG concentration and alcohol consumption in categories, linear regression analysis was performed. In addition, the association between EtG concentrations and indirect biomarkers was analyzed.

Results: Mean age was 53.7 y, and 52.9% of participants men. Of the self-reported abstainers, 92.3% had an EtG concentration

Conclusions: This study shows that urinary EtG is in reasonable agreement with self-reported alcohol consumption and therefore can be used as an objective marker of habitual alcohol consumption in the general population.

Original languageEnglish
Pages (from-to)2199-2205
Number of pages7
JournalJournal of Nutrition
Volume149
Issue number12
Early online date3-Jul-2019
Publication statusPublished - Dec-2019

    Keywords

  • ethyl glucuronide, habitual alcohol consumption, self-report, biomarker, general population, RISK-FACTOR, SULFATE, ETHANOL, ETHYLGLUCURONIDE, EXCRETION, DRINKING, MARKER

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