Urinary Ethyl Glucuronide Can Be Used as a Biomarker of Habitual Alcohol Consumption in the General Populationvan de Luitgaarden, I. A. T., Beulens, J. W. J., Schrieks, I. C., Kieneker, L. M., Touw, D. J., van Ballegooijen, A. J., van Oort, S., Grobbee, D. E. & Bakker, S. J. L., Dec-2019, In : Journal of Nutrition. 149, 12, p. 2199-2205 7 p.
Research output: Contribution to journal › Article › Academic › peer-review
- Pharmaceutical Analysis
- Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
- Groningen Research Institute for Asthma and COPD (GRIAC)
- Biopharmaceuticals, Discovery, Design and Delivery (BDDD)
- Pharmacokinetics, Toxicology and Targeting
- Lifestyle Medicine (LM)
- Groningen Institute for Organ Transplantation (GIOT)
- Groningen Kidney Center (GKC)
Background: Alcohol consumption is a frequently studied risk factor for chronic diseases, but many studies are hampered by self-report of alcohol consumption. The urinary metabolite ethyl glucuronide (EtG), reflecting alcohol consumption during the past 72 h, is a promising objective marker, but population data are lacking.
Objective: The objective of this study was to assess the reliability of EtG as a marker for habitual alcohol consumption compared with self-report and other biomarkers in the general population.
Methods: Among 6211 participants in the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, EtG concentrations were measured in 24-h urine samples. EtG was considered positive when concentrations were >= 100 ng/mL. Habitual alcohol consumption was self-reported by questionnaire (categories: no/almost never, 1-4 units per month, 2-7 units per week, 1-3 units per day or >= 4 units per day). Plasma HDL cholesterol concentration, erythrocyte mean corpuscular volume (MCV), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyltransferase (GGT) were determined as indirect biomarkers of alcohol consumption. Sensitivity, specificity, positive and negative predictive value, and proportions of agreement between reported consumption and EtG were calculated. To test the agreement of EtG concentration and alcohol consumption in categories, linear regression analysis was performed. In addition, the association between EtG concentrations and indirect biomarkers was analyzed.
Results: Mean age was 53.7 y, and 52.9% of participants men. Of the self-reported abstainers, 92.3% had an EtG concentration
Conclusions: This study shows that urinary EtG is in reasonable agreement with self-reported alcohol consumption and therefore can be used as an objective marker of habitual alcohol consumption in the general population.
|Number of pages||7|
|Journal||Journal of Nutrition|
|Early online date||3-Jul-2019|
|Publication status||Published - Dec-2019|
- ethyl glucuronide, habitual alcohol consumption, self-report, biomarker, general population, RISK-FACTOR, SULFATE, ETHANOL, ETHYLGLUCURONIDE, EXCRETION, DRINKING, MARKER