Publication

Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies

Post, A., Said, M. Y., Gomes-Neto, A. W., Minović, I., Groothof, D., Swarte, J. C., Boer, T., Kema, I. P., Heiner-Fokkema, M. R., Franssen, C. F. M. & Bakker, S. J. L., 2020, In : Clinical Nutrition. 12 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Post, A., Said, M. Y., Gomes-Neto, A. W., Minović, I., Groothof, D., Swarte, J. C., Boer, T., Kema, I. P., Heiner-Fokkema, M. R., Franssen, C. F. M., & Bakker, S. J. L. (2020). Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies. Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.09.035

Author

Post, Adrian ; Said, M Yusof ; Gomes-Neto, Antonio W ; Minović, Isidor ; Groothof, Dion ; Swarte, J Casper ; Boer, Theo ; Kema, Ido P ; Heiner-Fokkema, M Rebecca ; Franssen, Casper F M ; Bakker, Stephan J L. / Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients : Results from the TransplantLines cohort studies. In: Clinical Nutrition. 2020.

Harvard

Post, A, Said, MY, Gomes-Neto, AW, Minović, I, Groothof, D, Swarte, JC, Boer, T, Kema, IP, Heiner-Fokkema, MR, Franssen, CFM & Bakker, SJL 2020, 'Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies', Clinical Nutrition. https://doi.org/10.1016/j.clnu.2020.09.035

Standard

Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients : Results from the TransplantLines cohort studies. / Post, Adrian; Said, M Yusof; Gomes-Neto, Antonio W; Minović, Isidor; Groothof, Dion; Swarte, J Casper; Boer, Theo; Kema, Ido P; Heiner-Fokkema, M Rebecca; Franssen, Casper F M; Bakker, Stephan J L.

In: Clinical Nutrition, 2020.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Post A, Said MY, Gomes-Neto AW, Minović I, Groothof D, Swarte JC et al. Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies. Clinical Nutrition. 2020. https://doi.org/10.1016/j.clnu.2020.09.035


BibTeX

@article{91d5b63023444539b91b7cc2f26f1a8c,
title = "Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients: Results from the TransplantLines cohort studies",
abstract = "Background: Leucine is an essential amino acid and a potent stimulator of muscle protein synthesis. Since muscle wasting is a major risk factor for mortality in kidney transplant recipients (KTR), dietary leucine intake might be linked to long-term mortality. Urinary 3-hydroxyisovaleryl carnitine (3-HIC) excretion, a functional marker of marginal biotin deficiency, may also serve as a marker for dietary leucine intake. Objective: In this study we aimed to investigate the cross-sectional determinants of urinary 3-HIC excretion and to prospectively investigate the association of urinary 3-HIC excretion with all-cause mortality in KTR. Design: Urinary 3-HIC excretion and plasma biotin were measured in a longitudinal cohort of 694 stable KTR. Cross-sectional and prospective analyses were performed using ordinary least squares linear regression analyses and Cox regression analyses, respectively. Results: In KTR (57% male, 53 ± 13 years, estimated glomerular filtration rate 45 ± 19 mL/min/1.73 m2), urinary 3-HIC excretion (0.80 [0.57–1.16] μmol/24 h) was significantly associated with plasma biotin (std. β = −0.17; P < 0.001). Subsequent adjustment for potential covariates revealed urinary creatinine excretion (std. β = 0.24; P < 0.001) and urinary urea excretion (std. β = 0.53; P < 0.001) as the primary determinant of urinary 3-HIC excretion. Whereas plasma biotin explained only 1% of the variance in urinary 3-HIC excretion, urinary urea excretion explained >45%. During median follow-up for 5.4 [4.8–6.1] years, 150 (22%) patients died. Log2-transformed urinary 3-HIC excretion was inversely associated with all-cause mortality (HR: 0.52 [0.43–0.63]; P < 0.001). This association was independent of potential confounders. Conclusions: Urinary 3-HIC excretion more strongly serves as a marker of leucine intake than of biotin status. A higher urinary 3-HIC excretion is associated with a lower risk of all-cause mortality. Future studies are warranted to explore the underlying mechanism. Trial registration id: NCT02811835. Trial registration url: https://clinicaltrials.gov/ct2/show/NCT02811835.",
author = "Adrian Post and Said, {M Yusof} and Gomes-Neto, {Antonio W} and Isidor Minovi{\'c} and Dion Groothof and Swarte, {J Casper} and Theo Boer and Kema, {Ido P} and Heiner-Fokkema, {M Rebecca} and Franssen, {Casper F M} and Bakker, {Stephan J L}",
note = "Copyright {\textcopyright} 2020. Published by Elsevier Ltd.",
year = "2020",
doi = "10.1016/j.clnu.2020.09.035",
language = "English",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",

}

RIS

TY - JOUR

T1 - Urinary 3-hydroxyisovaleryl carnitine excretion, protein energy malnutrition and risk of all-cause mortality in kidney transplant recipients

T2 - Results from the TransplantLines cohort studies

AU - Post, Adrian

AU - Said, M Yusof

AU - Gomes-Neto, Antonio W

AU - Minović, Isidor

AU - Groothof, Dion

AU - Swarte, J Casper

AU - Boer, Theo

AU - Kema, Ido P

AU - Heiner-Fokkema, M Rebecca

AU - Franssen, Casper F M

AU - Bakker, Stephan J L

N1 - Copyright © 2020. Published by Elsevier Ltd.

PY - 2020

Y1 - 2020

N2 - Background: Leucine is an essential amino acid and a potent stimulator of muscle protein synthesis. Since muscle wasting is a major risk factor for mortality in kidney transplant recipients (KTR), dietary leucine intake might be linked to long-term mortality. Urinary 3-hydroxyisovaleryl carnitine (3-HIC) excretion, a functional marker of marginal biotin deficiency, may also serve as a marker for dietary leucine intake. Objective: In this study we aimed to investigate the cross-sectional determinants of urinary 3-HIC excretion and to prospectively investigate the association of urinary 3-HIC excretion with all-cause mortality in KTR. Design: Urinary 3-HIC excretion and plasma biotin were measured in a longitudinal cohort of 694 stable KTR. Cross-sectional and prospective analyses were performed using ordinary least squares linear regression analyses and Cox regression analyses, respectively. Results: In KTR (57% male, 53 ± 13 years, estimated glomerular filtration rate 45 ± 19 mL/min/1.73 m2), urinary 3-HIC excretion (0.80 [0.57–1.16] μmol/24 h) was significantly associated with plasma biotin (std. β = −0.17; P < 0.001). Subsequent adjustment for potential covariates revealed urinary creatinine excretion (std. β = 0.24; P < 0.001) and urinary urea excretion (std. β = 0.53; P < 0.001) as the primary determinant of urinary 3-HIC excretion. Whereas plasma biotin explained only 1% of the variance in urinary 3-HIC excretion, urinary urea excretion explained >45%. During median follow-up for 5.4 [4.8–6.1] years, 150 (22%) patients died. Log2-transformed urinary 3-HIC excretion was inversely associated with all-cause mortality (HR: 0.52 [0.43–0.63]; P < 0.001). This association was independent of potential confounders. Conclusions: Urinary 3-HIC excretion more strongly serves as a marker of leucine intake than of biotin status. A higher urinary 3-HIC excretion is associated with a lower risk of all-cause mortality. Future studies are warranted to explore the underlying mechanism. Trial registration id: NCT02811835. Trial registration url: https://clinicaltrials.gov/ct2/show/NCT02811835.

AB - Background: Leucine is an essential amino acid and a potent stimulator of muscle protein synthesis. Since muscle wasting is a major risk factor for mortality in kidney transplant recipients (KTR), dietary leucine intake might be linked to long-term mortality. Urinary 3-hydroxyisovaleryl carnitine (3-HIC) excretion, a functional marker of marginal biotin deficiency, may also serve as a marker for dietary leucine intake. Objective: In this study we aimed to investigate the cross-sectional determinants of urinary 3-HIC excretion and to prospectively investigate the association of urinary 3-HIC excretion with all-cause mortality in KTR. Design: Urinary 3-HIC excretion and plasma biotin were measured in a longitudinal cohort of 694 stable KTR. Cross-sectional and prospective analyses were performed using ordinary least squares linear regression analyses and Cox regression analyses, respectively. Results: In KTR (57% male, 53 ± 13 years, estimated glomerular filtration rate 45 ± 19 mL/min/1.73 m2), urinary 3-HIC excretion (0.80 [0.57–1.16] μmol/24 h) was significantly associated with plasma biotin (std. β = −0.17; P < 0.001). Subsequent adjustment for potential covariates revealed urinary creatinine excretion (std. β = 0.24; P < 0.001) and urinary urea excretion (std. β = 0.53; P < 0.001) as the primary determinant of urinary 3-HIC excretion. Whereas plasma biotin explained only 1% of the variance in urinary 3-HIC excretion, urinary urea excretion explained >45%. During median follow-up for 5.4 [4.8–6.1] years, 150 (22%) patients died. Log2-transformed urinary 3-HIC excretion was inversely associated with all-cause mortality (HR: 0.52 [0.43–0.63]; P < 0.001). This association was independent of potential confounders. Conclusions: Urinary 3-HIC excretion more strongly serves as a marker of leucine intake than of biotin status. A higher urinary 3-HIC excretion is associated with a lower risk of all-cause mortality. Future studies are warranted to explore the underlying mechanism. Trial registration id: NCT02811835. Trial registration url: https://clinicaltrials.gov/ct2/show/NCT02811835.

U2 - 10.1016/j.clnu.2020.09.035

DO - 10.1016/j.clnu.2020.09.035

M3 - Article

C2 - 33071013

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

ER -

ID: 136290700