Publication

Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture

Beishuizen, S. J. E., Scholtens, R. M., van Munster, B. C. & de Rooij, S. E., Jan-2017, In : Journal of the American Geriatrics Society. 65, 1, p. 130-136 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Beishuizen, S. J. E., Scholtens, R. M., van Munster, B. C., & de Rooij, S. E. (2017). Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture. Journal of the American Geriatrics Society, 65(1), 130-136. https://doi.org/10.1111/jgs.14470

Author

Beishuizen, Sara J E ; Scholtens, Rikie M. ; van Munster, Barbara C. ; de Rooij, Sophia E. / Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture. In: Journal of the American Geriatrics Society. 2017 ; Vol. 65, No. 1. pp. 130-136.

Harvard

Beishuizen, SJE, Scholtens, RM, van Munster, BC & de Rooij, SE 2017, 'Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture', Journal of the American Geriatrics Society, vol. 65, no. 1, pp. 130-136. https://doi.org/10.1111/jgs.14470

Standard

Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture. / Beishuizen, Sara J E; Scholtens, Rikie M.; van Munster, Barbara C.; de Rooij, Sophia E.

In: Journal of the American Geriatrics Society, Vol. 65, No. 1, 01.2017, p. 130-136.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Beishuizen SJE, Scholtens RM, van Munster BC, de Rooij SE. Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture. Journal of the American Geriatrics Society. 2017 Jan;65(1):130-136. https://doi.org/10.1111/jgs.14470


BibTeX

@article{ba52437949494c6db6d6aabdb3ddb292,
title = "Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture",
abstract = "ObjectivesTo assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline.DesignSubstudy of a multicenter randomized controlled trial.SettingSurgical, orthopedic, and trauma surgery wards of two teaching hospitals.ParticipantsIndividuals aged 65 and older (range 65-102) admitted for hip fracture surgery (N = 385).MeasurementsDuring hospitalization, presence of delirium was assessed daily. S100B was assayed in repeated serum samples. Twelve months after discharge, cognitive decline and mortality were evaluated. Cognitive decline was defined as an increase in Informant Questionnaire on Cognitive Decline Short Form score of 1 standard deviation or more or a decrease in Mini Mental State Examination score of 3 points or more between admission and 12 months after discharge.ResultsPremorbid cognitive impairment was present in 226 (58.7%) participants, and 127 (33.0%) experienced perioperative delirium. Multivariable analysis showed that older age and presence of infection, but not of delirium, were associated with higher S100B levels. Levels were also higher after surgery than before. Of participants with perioperative delirium, 58.6% experienced cognitive decline or death, and only age was a risk factor; 36.5% of participants without perioperative delirium experienced cognitive decline or death in the following year, and higher S100B, premorbid cognitive impairment, and older age were risk factors.ConclusionIn a cohort of older adults with hip fracture, no association was found between serum S100B levels and occurrence of delirium. S100B was associated with cognitive decline or death in the first year after hip fracture only in participants without perioperative delirium. S100B seems to be of limited value as a biomarker of brain damage associated with delirium.",
keywords = "S100B, delirium, brain damage, cognitive decline, hip fracture, NEURON-SPECIFIC ENOLASE, CEREBROSPINAL-FLUID, CARDIAC-SURGERY, DYSFUNCTION, BIOMARKERS, DEMENTIA, RISK",
author = "Beishuizen, {Sara J E} and Scholtens, {Rikie M.} and {van Munster}, {Barbara C.} and {de Rooij}, {Sophia E.}",
note = "{\textcopyright} 2016, Copyright the Authors Journal compilation {\textcopyright} 2016, The American Geriatrics Society.",
year = "2017",
month = jan,
doi = "10.1111/jgs.14470",
language = "English",
volume = "65",
pages = "130--136",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Unraveling the Relationship Between Delirium, Brain Damage, and Subsequent Cognitive Decline in a Cohort of Individuals Undergoing Surgery for Hip Fracture

AU - Beishuizen, Sara J E

AU - Scholtens, Rikie M.

AU - van Munster, Barbara C.

AU - de Rooij, Sophia E.

N1 - © 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.

PY - 2017/1

Y1 - 2017/1

N2 - ObjectivesTo assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline.DesignSubstudy of a multicenter randomized controlled trial.SettingSurgical, orthopedic, and trauma surgery wards of two teaching hospitals.ParticipantsIndividuals aged 65 and older (range 65-102) admitted for hip fracture surgery (N = 385).MeasurementsDuring hospitalization, presence of delirium was assessed daily. S100B was assayed in repeated serum samples. Twelve months after discharge, cognitive decline and mortality were evaluated. Cognitive decline was defined as an increase in Informant Questionnaire on Cognitive Decline Short Form score of 1 standard deviation or more or a decrease in Mini Mental State Examination score of 3 points or more between admission and 12 months after discharge.ResultsPremorbid cognitive impairment was present in 226 (58.7%) participants, and 127 (33.0%) experienced perioperative delirium. Multivariable analysis showed that older age and presence of infection, but not of delirium, were associated with higher S100B levels. Levels were also higher after surgery than before. Of participants with perioperative delirium, 58.6% experienced cognitive decline or death, and only age was a risk factor; 36.5% of participants without perioperative delirium experienced cognitive decline or death in the following year, and higher S100B, premorbid cognitive impairment, and older age were risk factors.ConclusionIn a cohort of older adults with hip fracture, no association was found between serum S100B levels and occurrence of delirium. S100B was associated with cognitive decline or death in the first year after hip fracture only in participants without perioperative delirium. S100B seems to be of limited value as a biomarker of brain damage associated with delirium.

AB - ObjectivesTo assess the association between serum S100B levels (a marker of brain damage), delirium, and subsequent cognitive decline.DesignSubstudy of a multicenter randomized controlled trial.SettingSurgical, orthopedic, and trauma surgery wards of two teaching hospitals.ParticipantsIndividuals aged 65 and older (range 65-102) admitted for hip fracture surgery (N = 385).MeasurementsDuring hospitalization, presence of delirium was assessed daily. S100B was assayed in repeated serum samples. Twelve months after discharge, cognitive decline and mortality were evaluated. Cognitive decline was defined as an increase in Informant Questionnaire on Cognitive Decline Short Form score of 1 standard deviation or more or a decrease in Mini Mental State Examination score of 3 points or more between admission and 12 months after discharge.ResultsPremorbid cognitive impairment was present in 226 (58.7%) participants, and 127 (33.0%) experienced perioperative delirium. Multivariable analysis showed that older age and presence of infection, but not of delirium, were associated with higher S100B levels. Levels were also higher after surgery than before. Of participants with perioperative delirium, 58.6% experienced cognitive decline or death, and only age was a risk factor; 36.5% of participants without perioperative delirium experienced cognitive decline or death in the following year, and higher S100B, premorbid cognitive impairment, and older age were risk factors.ConclusionIn a cohort of older adults with hip fracture, no association was found between serum S100B levels and occurrence of delirium. S100B was associated with cognitive decline or death in the first year after hip fracture only in participants without perioperative delirium. S100B seems to be of limited value as a biomarker of brain damage associated with delirium.

KW - S100B

KW - delirium

KW - brain damage

KW - cognitive decline

KW - hip fracture

KW - NEURON-SPECIFIC ENOLASE

KW - CEREBROSPINAL-FLUID

KW - CARDIAC-SURGERY

KW - DYSFUNCTION

KW - BIOMARKERS

KW - DEMENTIA

KW - RISK

U2 - 10.1111/jgs.14470

DO - 10.1111/jgs.14470

M3 - Article

C2 - 27641367

VL - 65

SP - 130

EP - 136

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 1

ER -

ID: 35558196