Publication

Ugi 4-CR synthesis of gamma- and delta-lactams providing new access to diverse enzyme interactions: a PDB analysis

Boltjes, A., Liao, G. P., Zhao, T., Herdtweck, E. & Doemling, A., 14-May-2014, In : MedChemCommun. 5, 7, p. 949-952 4 p.

Research output: Contribution to journalArticleAcademicpeer-review

Copy link to clipboard

Documents

  • Ugi 4-CR synthesis of gamma- and delta-lactams providing new access

    Final publisher's version, 378 KB, PDF document

    Request copy

DOI

A three step synthesis of N-unsubstituted tetrazolo gamma- and delta-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted gamma- and delta-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites.

Original languageEnglish
Pages (from-to)949-952
Number of pages4
JournalMedChemCommun
Volume5
Issue number7
Publication statusPublished - 14-May-2014

    Keywords

  • ENTEROVIRUS-71 INFECTION, PROMISING CANDIDATE, AMMONIA, RUPINTRIVIR, INHIBITORS, SURROGATE, PROTEASE, DESIGN

ID: 13323367