Publication

Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma

van Kempen, L. C. L. T., Rijntjes, J., Claes, A., Blokx, W. A. M., Gerritsen, M-J. P., Ruiter, D. J. & van Muijen, G. N. P., Nov-2004, In : JOURNAL OF PATHOLOGY. 204, 3, p. 333-339 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

van Kempen, L. C. L. T., Rijntjes, J., Claes, A., Blokx, W. A. M., Gerritsen, M-J. P., Ruiter, D. J., & van Muijen, G. N. P. (2004). Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma. JOURNAL OF PATHOLOGY, 204(3), 333-339. https://doi.org/10.1002/path.1659

Author

van Kempen, Léon C L T ; Rijntjes, Jos ; Claes, An ; Blokx, Willeke A M ; Gerritsen, Marie-Jeanne P ; Ruiter, Dirk J ; van Muijen, Goos N P. / Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma. In: JOURNAL OF PATHOLOGY. 2004 ; Vol. 204, No. 3. pp. 333-339.

Harvard

van Kempen, LCLT, Rijntjes, J, Claes, A, Blokx, WAM, Gerritsen, M-JP, Ruiter, DJ & van Muijen, GNP 2004, 'Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma', JOURNAL OF PATHOLOGY, vol. 204, no. 3, pp. 333-339. https://doi.org/10.1002/path.1659

Standard

Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma. / van Kempen, Léon C L T; Rijntjes, Jos; Claes, An; Blokx, Willeke A M; Gerritsen, Marie-Jeanne P; Ruiter, Dirk J; van Muijen, Goos N P.

In: JOURNAL OF PATHOLOGY, Vol. 204, No. 3, 11.2004, p. 333-339.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

van Kempen LCLT, Rijntjes J, Claes A, Blokx WAM, Gerritsen M-JP, Ruiter DJ et al. Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma. JOURNAL OF PATHOLOGY. 2004 Nov;204(3):333-339. https://doi.org/10.1002/path.1659


BibTeX

@article{be0eda5acd0e43d3970ad81990c9ba5b,
title = "Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma",
abstract = "Neoplastic progression of solid tumours is often characterized by a simultaneous increase in matrix protein (eg collagen) synthesis and degradation, and results in the formation of a tumour stroma. At the tumour periphery, this process is believed to facilitate angiogenesis and invasive growth of tumour cells. In various types of carcinoma, differentiation of fibroblasts towards myofibroblasts is thought to play an important role in extracellular matrix remodelling as their emergence coincides with architectural changes in the tumour stroma. Here, distinct architectural changes in collagen fibres are reported in cutaneous squamous cell carcinomas (cSCC) with respect to normal skin and precursor lesions, ie keratinocytic intraepidermal neoplasia (KIN). Simultaneously, type I collagen mRNA was observed in fibroblasts in close proximity to cSCC lesions (19/19) but only in 2 of 10 KIN lesions tested. Interestingly, whereas emerging of myofibroblasts correlated with reduced differentiation of cSCCs, it was not a prerequisite for type I collagen synthesis. These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC.",
keywords = "Carcinoma in Situ/metabolism, Carcinoma, Squamous Cell/metabolism, Cell Transformation, Neoplastic/metabolism, Collagen Type I/biosynthesis, Epidermis/pathology, Extracellular Matrix/metabolism, Fibroblasts/physiology, Humans, Immunohistochemistry/methods, In Situ Hybridization/methods, Keratinocytes/pathology, RNA, Messenger/analysis, RNA, Neoplasm/analysis, Skin Neoplasms/metabolism",
author = "{van Kempen}, {L{\'e}on C L T} and Jos Rijntjes and An Claes and Blokx, {Willeke A M} and Gerritsen, {Marie-Jeanne P} and Ruiter, {Dirk J} and {van Muijen}, {Goos N P}",
note = "Copyright (c) 2004 Pathological Society of Great Britain and Ireland.",
year = "2004",
month = "11",
doi = "10.1002/path.1659",
language = "English",
volume = "204",
pages = "333--339",
journal = "JOURNAL OF PATHOLOGY",
issn = "0022-3417",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma

AU - van Kempen, Léon C L T

AU - Rijntjes, Jos

AU - Claes, An

AU - Blokx, Willeke A M

AU - Gerritsen, Marie-Jeanne P

AU - Ruiter, Dirk J

AU - van Muijen, Goos N P

N1 - Copyright (c) 2004 Pathological Society of Great Britain and Ireland.

PY - 2004/11

Y1 - 2004/11

N2 - Neoplastic progression of solid tumours is often characterized by a simultaneous increase in matrix protein (eg collagen) synthesis and degradation, and results in the formation of a tumour stroma. At the tumour periphery, this process is believed to facilitate angiogenesis and invasive growth of tumour cells. In various types of carcinoma, differentiation of fibroblasts towards myofibroblasts is thought to play an important role in extracellular matrix remodelling as their emergence coincides with architectural changes in the tumour stroma. Here, distinct architectural changes in collagen fibres are reported in cutaneous squamous cell carcinomas (cSCC) with respect to normal skin and precursor lesions, ie keratinocytic intraepidermal neoplasia (KIN). Simultaneously, type I collagen mRNA was observed in fibroblasts in close proximity to cSCC lesions (19/19) but only in 2 of 10 KIN lesions tested. Interestingly, whereas emerging of myofibroblasts correlated with reduced differentiation of cSCCs, it was not a prerequisite for type I collagen synthesis. These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC.

AB - Neoplastic progression of solid tumours is often characterized by a simultaneous increase in matrix protein (eg collagen) synthesis and degradation, and results in the formation of a tumour stroma. At the tumour periphery, this process is believed to facilitate angiogenesis and invasive growth of tumour cells. In various types of carcinoma, differentiation of fibroblasts towards myofibroblasts is thought to play an important role in extracellular matrix remodelling as their emergence coincides with architectural changes in the tumour stroma. Here, distinct architectural changes in collagen fibres are reported in cutaneous squamous cell carcinomas (cSCC) with respect to normal skin and precursor lesions, ie keratinocytic intraepidermal neoplasia (KIN). Simultaneously, type I collagen mRNA was observed in fibroblasts in close proximity to cSCC lesions (19/19) but only in 2 of 10 KIN lesions tested. Interestingly, whereas emerging of myofibroblasts correlated with reduced differentiation of cSCCs, it was not a prerequisite for type I collagen synthesis. These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC.

KW - Carcinoma in Situ/metabolism

KW - Carcinoma, Squamous Cell/metabolism

KW - Cell Transformation, Neoplastic/metabolism

KW - Collagen Type I/biosynthesis

KW - Epidermis/pathology

KW - Extracellular Matrix/metabolism

KW - Fibroblasts/physiology

KW - Humans

KW - Immunohistochemistry/methods

KW - In Situ Hybridization/methods

KW - Keratinocytes/pathology

KW - RNA, Messenger/analysis

KW - RNA, Neoplasm/analysis

KW - Skin Neoplasms/metabolism

U2 - 10.1002/path.1659

DO - 10.1002/path.1659

M3 - Article

VL - 204

SP - 333

EP - 339

JO - JOURNAL OF PATHOLOGY

JF - JOURNAL OF PATHOLOGY

SN - 0022-3417

IS - 3

ER -

ID: 120136312