Publication

Twin-Arginine Protein Translocation

Goosens, V. J. & van Dijl, J. M., 2017, Protein and Sugar Export and Assembly in Gram-positive Bacteria. Bagnoli, F. & Rappuoli, R. (eds.). SPRINGER-VERLAG BERLIN, Vol. 404. p. 69-94 26 p. (Current Topics in Microbiology and Immunology; vol. 404).

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  • 10.1007%2F978-3-319-56014-4 (1)

    Final publisher's version, 6 MB, PDF-document

DOI

Twin-arginine protein translocation systems (Tat) translocate fully folded and co-factor-containing proteins across biological membranes. In this review, we focus on the Tat pathway of Gram-positive bacteria. The minimal Tat pathway is composed of two components, namely a TatA and TatC pair, which are often complemented with additional TatA-like proteins. We provide overviews of our current understanding of Tat pathway composition and mechanistic aspects related to Tat-dependent cargo protein translocation. This includes Tat pathway flexibility, requirements for the correct folding and incorporation of co-factors in cargo proteins and the functions of known cargo proteins. Tat pathways of several Gram-positive bacteria are discussed in detail, with emphasis on the Tat pathway of Bacillus subtilis. We discuss both shared and unique features of the different Gram-positive bacterial Tat pathways. Lastly, we highlight topics for future research on Tat, including the development of this protein transport pathway for the biotechnological secretion of high-value proteins and its potential applicability as an antimicrobial drug target in pathogens.

Original languageEnglish
Title of host publicationProtein and Sugar Export and Assembly in Gram-positive Bacteria
EditorsFabio Bagnoli, Rino Rappuoli
PublisherSPRINGER-VERLAG BERLIN
Pages69-94
Number of pages26
Volume404
ISBN (Electronic)978-3-319-56014-4
ISBN (Print)978-3-319-56012-0
Publication statusPublished - 2017

Publication series

NameCurrent Topics in Microbiology and Immunology
PublisherSPRINGER-VERLAG BERLIN
Volume404
ISSN (Print)0070-217X

    Keywords

  • BACTERIUM BACILLUS-SUBTILIS, COMPLETE GENOME SEQUENCE, SEC-INDEPENDENT PROTEIN, FOLDING QUALITY-CONTROL, WATER-SOLUBLE FRAGMENT, LEADER-BINDING PROTEIN, TAT SIGNAL PEPTIDES, IRON-SULFUR PROTEIN, RIESKE FE/S PROTEIN, ESCHERICHIA-COLI

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