Publication

Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview

2016 EV-D68 AFM Working Group, 7-Jan-2019, In : Pediatric infectious disease journal. 38, 1, p. 16-21 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

2016 EV-D68 AFM Working Group (2019). Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview. Pediatric infectious disease journal, 38(1), 16-21. https://doi.org/10.1097/INF.0000000000002188

Author

2016 EV-D68 AFM Working Group. / Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview. In: Pediatric infectious disease journal. 2019 ; Vol. 38, No. 1. pp. 16-21.

Harvard

2016 EV-D68 AFM Working Group 2019, 'Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview' Pediatric infectious disease journal, vol. 38, no. 1, pp. 16-21. https://doi.org/10.1097/INF.0000000000002188

Standard

Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview. / 2016 EV-D68 AFM Working Group.

In: Pediatric infectious disease journal, Vol. 38, No. 1, 07.01.2019, p. 16-21.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

2016 EV-D68 AFM Working Group. Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview. Pediatric infectious disease journal. 2019 Jan 7;38(1):16-21. https://doi.org/10.1097/INF.0000000000002188


BibTeX

@article{9ee9322627fc4fb0b0e5adbd7a9ffeb8,
title = "Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview",
abstract = "Background: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates in the respiratory tract and causes respiratory disease. Since 2014, EV-D68 has been associated with the neurologic syndrome of acute flaccid myelitis (AFM). Methods: In October 2016, questionnaires were sent out to a European network including 66 virologists and clinicians, to develop an inventory of EVD68- associated AFM cases in Europe. Clinical and virologic information of case patients was requested. In addition, epidemiologic information on EV testing was collected for the period between March and October 2016.Results: Twenty-nine cases of EV-D68-associated AFM were identified, from 12 different European countries. Five originated from France, 5 from Scotland and 3 each from Sweden, Norway and Spain. Twenty-six were children (median age 3.8 years), 3 were adults. EV-D68 was detected in respiratory materials (n = 27), feces (n = 8) and/or cerebrospinal fluid (n = 2). Common clinical features were asymmetric flaccid limb weakness, cranial nerve deficits and bulbar symptoms. On magnetic resonance imaging, typical findings were hyperintensity of the central cord and/or brainstem; low motor amplitudes with normal conduction velocities were seen on electromyography. Full clinical recovery was rare (n = 3), and 2 patients died. The epidemiologic data from 16 European laboratories showed that of all EV-D68-positive samples, 99{\%} was detected in a respiratory specimen.Conclusions: For 2016, 29 EV-D68-related AFM cases were identified in mostly Western Europe. This is likely an underestimation, because case identification is dependent on awareness among clinicians, adequate viral diagnostics on respiratory samples and the capability of laboratories to type EVs.",
keywords = "paralysis, myelitis, enterovirus, enterovirus D68, laboratory surveillance, ENTEROVIRUS D68 INFECTION, UPPER RESPIRATORY-TRACT, NEUROLOGICAL ILLNESS, CHILDREN, PARALYSIS, OUTBREAK, CLUSTER, EV-D68, AUGUST, IDENTIFICATION",
author = "{2016 EV-D68 AFM Working Group} and Marjolein Knoester and Jelte Helfferich and Randy Poelman and {Van Leer-Buter}, Coretta and Brouwer, {Oebele F} and Niesters, {Hubert G M}",
year = "2019",
month = "1",
day = "7",
doi = "10.1097/INF.0000000000002188",
language = "English",
volume = "38",
pages = "16--21",
journal = "Pediatric infectious disease journal",
issn = "0891-3668",
publisher = "LIPPINCOTT WILLIAMS & WILKINS",
number = "1",

}

RIS

TY - JOUR

T1 - Twenty-nine Cases of Enterovirus-D68-associated Acute Flaccid Myelitis in Europe 2016 A Case Series and Epidemiologic Overview

AU - 2016 EV-D68 AFM Working Group

AU - Knoester, Marjolein

AU - Helfferich, Jelte

AU - Poelman, Randy

AU - Van Leer-Buter, Coretta

AU - Brouwer, Oebele F

AU - Niesters, Hubert G M

PY - 2019/1/7

Y1 - 2019/1/7

N2 - Background: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates in the respiratory tract and causes respiratory disease. Since 2014, EV-D68 has been associated with the neurologic syndrome of acute flaccid myelitis (AFM). Methods: In October 2016, questionnaires were sent out to a European network including 66 virologists and clinicians, to develop an inventory of EVD68- associated AFM cases in Europe. Clinical and virologic information of case patients was requested. In addition, epidemiologic information on EV testing was collected for the period between March and October 2016.Results: Twenty-nine cases of EV-D68-associated AFM were identified, from 12 different European countries. Five originated from France, 5 from Scotland and 3 each from Sweden, Norway and Spain. Twenty-six were children (median age 3.8 years), 3 were adults. EV-D68 was detected in respiratory materials (n = 27), feces (n = 8) and/or cerebrospinal fluid (n = 2). Common clinical features were asymmetric flaccid limb weakness, cranial nerve deficits and bulbar symptoms. On magnetic resonance imaging, typical findings were hyperintensity of the central cord and/or brainstem; low motor amplitudes with normal conduction velocities were seen on electromyography. Full clinical recovery was rare (n = 3), and 2 patients died. The epidemiologic data from 16 European laboratories showed that of all EV-D68-positive samples, 99% was detected in a respiratory specimen.Conclusions: For 2016, 29 EV-D68-related AFM cases were identified in mostly Western Europe. This is likely an underestimation, because case identification is dependent on awareness among clinicians, adequate viral diagnostics on respiratory samples and the capability of laboratories to type EVs.

AB - Background: Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and the family of Picornaviridae. Genetically, it is closely related to rhinovirus that replicates in the respiratory tract and causes respiratory disease. Since 2014, EV-D68 has been associated with the neurologic syndrome of acute flaccid myelitis (AFM). Methods: In October 2016, questionnaires were sent out to a European network including 66 virologists and clinicians, to develop an inventory of EVD68- associated AFM cases in Europe. Clinical and virologic information of case patients was requested. In addition, epidemiologic information on EV testing was collected for the period between March and October 2016.Results: Twenty-nine cases of EV-D68-associated AFM were identified, from 12 different European countries. Five originated from France, 5 from Scotland and 3 each from Sweden, Norway and Spain. Twenty-six were children (median age 3.8 years), 3 were adults. EV-D68 was detected in respiratory materials (n = 27), feces (n = 8) and/or cerebrospinal fluid (n = 2). Common clinical features were asymmetric flaccid limb weakness, cranial nerve deficits and bulbar symptoms. On magnetic resonance imaging, typical findings were hyperintensity of the central cord and/or brainstem; low motor amplitudes with normal conduction velocities were seen on electromyography. Full clinical recovery was rare (n = 3), and 2 patients died. The epidemiologic data from 16 European laboratories showed that of all EV-D68-positive samples, 99% was detected in a respiratory specimen.Conclusions: For 2016, 29 EV-D68-related AFM cases were identified in mostly Western Europe. This is likely an underestimation, because case identification is dependent on awareness among clinicians, adequate viral diagnostics on respiratory samples and the capability of laboratories to type EVs.

KW - paralysis

KW - myelitis

KW - enterovirus

KW - enterovirus D68

KW - laboratory surveillance

KW - ENTEROVIRUS D68 INFECTION

KW - UPPER RESPIRATORY-TRACT

KW - NEUROLOGICAL ILLNESS

KW - CHILDREN

KW - PARALYSIS

KW - OUTBREAK

KW - CLUSTER

KW - EV-D68

KW - AUGUST

KW - IDENTIFICATION

U2 - 10.1097/INF.0000000000002188

DO - 10.1097/INF.0000000000002188

M3 - Article

VL - 38

SP - 16

EP - 21

JO - Pediatric infectious disease journal

JF - Pediatric infectious disease journal

SN - 0891-3668

IS - 1

ER -

ID: 65537842