Publication

Tryptophan metabolism: entering the field of aging and age-related pathologies

van der Goot, A. T. & Nollen, E. A. A., Jun-2013, In : TRENDS IN MOLECULAR MEDICINE. 19, 6, p. 336-344 9 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase lifespan. Recent studies in multiple organisms have implicated tryptophan metabolism as a powerful regulator of age-related diseases and lifespan. Its high conservation throughout evolution has enabled studies that begin to dissect the contribution of individual enzymes and metabolites. Here, we focus on the emerging view of tryptophan metabolism as a pathway that integrates environmental and metabolic signals to regulate animal biology and health.

Original languageEnglish
Pages (from-to)336-344
Number of pages9
JournalTRENDS IN MOLECULAR MEDICINE
Volume19
Issue number6
Publication statusPublished - Jun-2013

    Keywords

  • tryptophan, TDO-2, kynurenine pathway, aging, neurodegeneration, protein homeostasis, age-related diseases, LIFE-SPAN EXTENSION, INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY, GENETICALLY HETEROGENEOUS MICE, TUMORAL IMMUNE RESISTANCE, T-CELL PROLIFERATION, INSULIN-RECEPTOR, C-ELEGANS, CAENORHABDITIS-ELEGANS, HUNTINGTONS-DISEASE, DIETARY RESTRICTION

ID: 5900974