Publication

Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions

van Doormaal, J. J., van der Veer, E., van Voorst Vader, P. C., Kluin, P. M., Mulder, A. B., van der Heide, S., Arends, S., Kluin-Nelemans, J. C., Oude Elberink, J. N. G. & de Monchy, J. G. R., May-2012, In : Allergy. 67, 5, p. 683-690 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background: Risk indicators of indolent systemic mastocytosis (ISM) in adults with clinical suspicion of ISM without accompanying skin lesions [urticaria pigmentosa (UP)] are lacking. This study aimed at creating a decision tree using clinical characteristics, serum tryptase, and the urinary histamine metabolites methylimidazole acetic acid (MIMA) and methylhistamine (MH) to select patients for bone marrow investigations to diagnose ISM.

Methods: Retrospective data analysis of all adults, in whom bone marrow investigations were performed to diagnose ISM, was carried out.

Results: In total, 142 patients were included. SM was absent in all 44 patients with tryptase = 10 mu g/l and in 18 of 52 patients (35%) with tryptase > 20 mu g/l. Above 43 mu g/l, all patients had ISM (n = 11). Male gender, insect venom anaphylaxis as presenting symptom, tryptase, MIMA, and MH were independent ISM predictors. If tryptase was >= 10 mu g/l, the diagnostic accuracy of MIMA and MH was high (areas under the ROC curve 0.92).

Conclusions: In suspected patients without UP, the ISM risk is very low (if present at all) if tryptase is = 10 mu g/l, this risk depends on MIMA and MH, being low if these are normal, but high if these are elevated. Male gender and insect venom anaphylaxis are additional risk indicators. We recommend refraining from bone marrow examinations in suspected patients without UP if tryptase is 20 mu g/l.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalAllergy
Volume67
Issue number5
Publication statusPublished - May-2012

    Keywords

  • bone marrow, histamine metabolites, indolent systemic mastocytosis, tryptase, NITROGEN-PHOSPHORUS DETECTION, BLOOD MONONUCLEAR-CELLS, N-TAU-METHYLHISTAMINE, C-KIT MUTATION, URINE, EXCRETION, DISORDERS, MARKERS

ID: 5541604