Publication

Tritylamine as an Ammonia Surrogate in the Ugi Tetrazole Synthesis

Zhao, T., Boltjes, A., Herdtweck, E. & Doemling, A., 1-Feb-2013, In : Organic letters. 15, 3, p. 639-641 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

The role of tritylamine is introduced as a convenient ammonia substitute in the Ugi tetrazole synthesis. Fifteen examples and their mild cleavage products are described In satisfactory to good yields. N-Unsubstituted alpha-aminotetrazoles are important compounds with annotated biological activities, and the described two-step synthesis provided an alternative route to otherwise difficult to access derivatives.

Original languageEnglish
Pages (from-to)639-641
Number of pages3
JournalOrganic letters
Volume15
Issue number3
Publication statusPublished - 1-Feb-2013

    Keywords

  • 4-COMPONENT REACTION, DERIVATIVES, ACID

ID: 5782140