Publication

Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels

Hannefors, A-K., Hellgren, C., Schijven, D., Iliadis, S., Comasco, E., Skalkidou, A., Olivier, J. D. A. & Sundstrom-Poromaa, I. S., Aug-2015, In : Psychoneuroendocrinology. 58, p. 104-113 10 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Hannefors, A-K., Hellgren, C., Schijven, D., Iliadis, S., Comasco, E., Skalkidou, A., ... Sundstrom-Poromaa, I. S. (2015). Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels. Psychoneuroendocrinology, 58, 104-113. https://doi.org/10.1016/j.psyneuen.2015.04.009

Author

Hannefors, A.-K. ; Hellgren, C. ; Schijven, D ; Iliadis, S ; Comasco, E. ; Skalkidou, A. ; Olivier, J. D. A. ; Sundstrom-Poromaa, I. Sundstrom. / Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels. In: Psychoneuroendocrinology. 2015 ; Vol. 58. pp. 104-113.

Harvard

Hannefors, A-K, Hellgren, C, Schijven, D, Iliadis, S, Comasco, E, Skalkidou, A, Olivier, JDA & Sundstrom-Poromaa, IS 2015, 'Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels', Psychoneuroendocrinology, vol. 58, pp. 104-113. https://doi.org/10.1016/j.psyneuen.2015.04.009

Standard

Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels. / Hannefors, A.-K.; Hellgren, C.; Schijven, D; Iliadis, S; Comasco, E.; Skalkidou, A.; Olivier, J. D. A.; Sundstrom-Poromaa, I. Sundstrom.

In: Psychoneuroendocrinology, Vol. 58, 08.2015, p. 104-113.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Hannefors A-K, Hellgren C, Schijven D, Iliadis S, Comasco E, Skalkidou A et al. Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels. Psychoneuroendocrinology. 2015 Aug;58:104-113. https://doi.org/10.1016/j.psyneuen.2015.04.009


BibTeX

@article{43471500cb6b436392c7b646e6876d3c,
title = "Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels",
abstract = "Treatment with serotonin reuptake inhibitors (SSRI) has been associated with an increased risk of preterm birth, but causality remains unclear. While placental CRH production is correlated with gestational length and preterm birth, it has been difficult to establish if psychological stress or mental health problems are associated with increased CRH levels. This study compared second trimester CRH serum concentrations in pregnant women on SSRI treatment (n=207) with untreated depressed women (n=56) and controls (n=609). A secondary aim was to investigate the combined effect of SSRI treatment and CRH levels on gestational length and risk for preterm birth. Women on SSRI treatment had significantly higher second trimester CRH levels than controls, and untreated depressed women. CRH levels and SSRI treatment were independently associated with shorter gestational length. The combined effect of SSRI treatment and high CRH levels yielded the highest risk estimate for preterm birth. SSRI treatment during pregnancy is associated with increased CRH levels. However, the elevated risk for preterm birth in SSRI users appear not to be mediated by increased placental CRH production, instead CRH appear as an independent risk factor for shorter gestational length and preterm birth.",
keywords = "Corticotropin releasing hormone, depression, gestational length, Pregnancy, Preterm birth, Serotonin reuptake inhibitor",
author = "A.-K. Hannefors and C. Hellgren and D Schijven and S Iliadis and E. Comasco and A. Skalkidou and Olivier, {J. D. A.} and Sundstrom-Poromaa, {I. Sundstrom}",
year = "2015",
month = "8",
doi = "10.1016/j.psyneuen.2015.04.009",
language = "English",
volume = "58",
pages = "104--113",
journal = "Psychoneuroendocrinology",
issn = "0306-4530",
publisher = "PERGAMON-ELSEVIER SCIENCE LTD",

}

RIS

TY - JOUR

T1 - Treatment with serotonin reuptake inhibitors during pregnancy is associated with elevated corticotropin-releasing hormone levels

AU - Hannefors, A.-K.

AU - Hellgren, C.

AU - Schijven, D

AU - Iliadis, S

AU - Comasco, E.

AU - Skalkidou, A.

AU - Olivier, J. D. A.

AU - Sundstrom-Poromaa, I. Sundstrom

PY - 2015/8

Y1 - 2015/8

N2 - Treatment with serotonin reuptake inhibitors (SSRI) has been associated with an increased risk of preterm birth, but causality remains unclear. While placental CRH production is correlated with gestational length and preterm birth, it has been difficult to establish if psychological stress or mental health problems are associated with increased CRH levels. This study compared second trimester CRH serum concentrations in pregnant women on SSRI treatment (n=207) with untreated depressed women (n=56) and controls (n=609). A secondary aim was to investigate the combined effect of SSRI treatment and CRH levels on gestational length and risk for preterm birth. Women on SSRI treatment had significantly higher second trimester CRH levels than controls, and untreated depressed women. CRH levels and SSRI treatment were independently associated with shorter gestational length. The combined effect of SSRI treatment and high CRH levels yielded the highest risk estimate for preterm birth. SSRI treatment during pregnancy is associated with increased CRH levels. However, the elevated risk for preterm birth in SSRI users appear not to be mediated by increased placental CRH production, instead CRH appear as an independent risk factor for shorter gestational length and preterm birth.

AB - Treatment with serotonin reuptake inhibitors (SSRI) has been associated with an increased risk of preterm birth, but causality remains unclear. While placental CRH production is correlated with gestational length and preterm birth, it has been difficult to establish if psychological stress or mental health problems are associated with increased CRH levels. This study compared second trimester CRH serum concentrations in pregnant women on SSRI treatment (n=207) with untreated depressed women (n=56) and controls (n=609). A secondary aim was to investigate the combined effect of SSRI treatment and CRH levels on gestational length and risk for preterm birth. Women on SSRI treatment had significantly higher second trimester CRH levels than controls, and untreated depressed women. CRH levels and SSRI treatment were independently associated with shorter gestational length. The combined effect of SSRI treatment and high CRH levels yielded the highest risk estimate for preterm birth. SSRI treatment during pregnancy is associated with increased CRH levels. However, the elevated risk for preterm birth in SSRI users appear not to be mediated by increased placental CRH production, instead CRH appear as an independent risk factor for shorter gestational length and preterm birth.

KW - Corticotropin releasing hormone

KW - depression

KW - gestational length

KW - Pregnancy

KW - Preterm birth

KW - Serotonin reuptake inhibitor

U2 - 10.1016/j.psyneuen.2015.04.009

DO - 10.1016/j.psyneuen.2015.04.009

M3 - Article

VL - 58

SP - 104

EP - 113

JO - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 0306-4530

ER -

ID: 20912934