Publication

Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis

Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E. A., Abbas, F., D'Aiuto, F., Kastelein, J. J. P. & Loos, B. G., Jan-2014, In : Journal of Clinical Periodontology. 41, 1, p. 70-79 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

  • Wijnand J. Teeuw
  • Dagmar E. Slot
  • Hendri Susanto
  • Victor E. A. Gerdes
  • Frank Abbas
  • Francesco D'Aiuto
  • John J. P. Kastelein
  • Bruno G. Loos

AimSystematic review and meta-analyses to study the robustness of observations that treatment of periodontitis improves the atherosclerotic profile.

Material and MethodsLiterature was searched in Medline-PubMed, Cochrane CENTRAL and EMBASE, based on controlled periodontal intervention trials, including also a non-intervention group. Data were extracted and meta-analyses were performed.

ResultsFrom 3928 screened studies, 25 trials met the eligibility criteria. These trials enrolled 1748 periodontitis patients. Seven trials enrolled periodontitis patients that were otherwise healthy, 18 trials recruited periodontal patients with various co-morbidities, such as CVD or diabetes. None of the trials used hard clinical endpoints of CVD. However, improvement of endothelial function has been consistently reported. Meta-analyses demonstrated significant weighted mean difference (WMD) for hsCRP (-0.50mg/l, 95% CI:-0.78; -0.22), IL-6 (-0.48ng/l, 95% CI: -0.90; -0.06), TNF- (-0.75pg/ml, 95% CI: -1.34; -0.17), fibrinogen (-0.47g/l, 95% CI: -0.76; -0.17), total cholesterol (-0.11mmol/l, 95% CI: -0.21; -0.01) and HDL-C (0.04mmol/l, 95% CI: 0.03; 0.06) favouring periodontal intervention. Importantly, periodontitis patients with co-morbidity benefitted most from periodontal therapy; significant WMD were observed for levels of hsCRP (-0.71mg/l, 95% CI: -1.05; -0.36), IL-6 (-0.87ng/l, 95% CI: -0.97; -0.78), triglycerides (-0.24mmol/l, 95% CI: -0.26; -0.22), total cholesterol (-0.15mmol/l, 95% CI: -0.29; -0.01), HDL-C (0.05mmol/l, 95% CI: 0.03; 0.06) and HbA(1c) (-0.43%, 95% CI: -0.60; -0.25).

ConclusionsThis systematic review and meta-analyses demonstrate that periodontal treatment improves endothelial function and reduces biomarkers of atherosclerotic disease, especially in those already suffering from CVD and/or diabetes.

Original languageEnglish
Pages (from-to)70-79
Number of pages10
JournalJournal of Clinical Periodontology
Volume41
Issue number1
Publication statusPublished - Jan-2014

    Keywords

  • atherosclerosis, periodontitis, systematic review, therapy, C-REACTIVE PROTEIN, RANDOMIZED CONTROLLED-TRIAL, CORONARY-HEART-DISEASE, CARDIOVASCULAR-DISEASE, INFLAMMATORY MARKERS, METABOLIC-CONTROL, ENDOTHELIAL FUNCTION, PREGNANCY OUTCOMES, BARIATRIC SURGERY, VASCULAR-DISEASE

ID: 6005553