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Transient Substrate-Induced Catalyst Formation in a Dynamic Molecular Network

Fanlo-Virgos, H., Alba, A-N. R., Hamieh, S., Colomb-Delsuc, M. & Otto, S., 13-Oct-2014, In : Angewandte Chemie - International Edition. 53, 42, p. 11346-11350 5 p.

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  • Transient Substrate-Induced Catalyst Formation in a Dynamic Molecular Network

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DOI

  • Hugo Fanlo-Virgos
  • Andrea-Nekane R. Alba
  • Saleh Hamieh
  • Mathieu Colomb-Delsuc
  • Sijbren Otto

In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms are underdeveloped. We now report how a substrate of a chemical reaction induces the formation of its own catalyst from a dynamic molecular network. After complete conversion of the substrate, the network disassembles the catalyst. These results open up new opportunities for controlling catalysis in synthetic chemical systems.

Original languageEnglish
Pages (from-to)11346-11350
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number42
Publication statusPublished - 13-Oct-2014

    Keywords

  • aza-Cope rearrangement, combinatorial chemistry, dynamic molecular networks, supramolecular chemistry, systems chemistry, SUPRAMOLECULAR CATALYSIS, COMBINATORIAL LIBRARIES, DIELS-ALDER, EFFICIENT CATALYSIS, SYNTHETIC RECEPTOR, SYSTEMS CHEMISTRY, AQUEOUS-SOLUTION, RECOGNITION, SELECTION, AMPLIFICATION

ID: 20849528