Publication

Trained immunity: consequences for the heterologous effects of BCG vaccination

Kleinnijenhuis, J., van Crevel, R. & Netea, M. G., Jan-2015, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 109, 1, p. 29-35 7 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Kleinnijenhuis, J., van Crevel, R., & Netea, M. G. (2015). Trained immunity: consequences for the heterologous effects of BCG vaccination. Transactions of the Royal Society of Tropical Medicine and Hygiene, 109(1), 29-35. https://doi.org/10.1093/trstmh/tru168

Author

Kleinnijenhuis, Johanneke ; van Crevel, Reinout ; Netea, Mihai G. / Trained immunity : consequences for the heterologous effects of BCG vaccination. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015 ; Vol. 109, No. 1. pp. 29-35.

Harvard

Kleinnijenhuis, J, van Crevel, R & Netea, MG 2015, 'Trained immunity: consequences for the heterologous effects of BCG vaccination', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 109, no. 1, pp. 29-35. https://doi.org/10.1093/trstmh/tru168

Standard

Trained immunity : consequences for the heterologous effects of BCG vaccination. / Kleinnijenhuis, Johanneke; van Crevel, Reinout; Netea, Mihai G.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 109, No. 1, 01.2015, p. 29-35.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Kleinnijenhuis J, van Crevel R, Netea MG. Trained immunity: consequences for the heterologous effects of BCG vaccination. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2015 Jan;109(1):29-35. https://doi.org/10.1093/trstmh/tru168


BibTeX

@article{8e7eccbdd9164c48b64601f2d81fc53c,
title = "Trained immunity: consequences for the heterologous effects of BCG vaccination",
abstract = "A growing body of evidence from epidemiologic and immunologic studies have shown that in addition to target disease-specific effects, vaccines have heterologous effects towards unrelated pathogens. Like some other vaccines, bacille Calmette-Guerin (BCG) has shown in observational studies and randomized clinical trials to increase survival beyond the disease burden of the target disease. The immunologic substrate for these non-specific protective effects have been ascertained to heterologous T cell effects on the one hand, and to priming of innate immunity on the other hand. The term 'trained immunity' has been proposed to describe these potentiating effects of vaccines on innate immune responses. This process can explain the rapid effects of BCG vaccination and has been suggested to be mediated by epigenetic programming of monocytes or macrophages. This novel concept has important implications for the possible use of vaccines, for vaccination policy and even for the design of novel immunotherapeutic approaches.",
keywords = "BCG, Innate immunity, Heterologous effects, Trained immunity, Vaccine, BACILLUS-CALMETTE-GUERIN, SUPERFICIAL BLADDER-CANCER, MALIGNANT-MELANOMA, RANDOMIZED-TRIAL, MYCOBACTERIUM-TUBERCULOSIS, ACTIVATED MACROPHAGES, CHILD-MORTALITY, MEASLES-VACCINE, GUINEA-BISSAU, IMMUNOTHERAPY",
author = "Johanneke Kleinnijenhuis and {van Crevel}, Reinout and Netea, {Mihai G.}",
year = "2015",
month = "1",
doi = "10.1093/trstmh/tru168",
language = "English",
volume = "109",
pages = "29--35",
journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",
issn = "0035-9203",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Trained immunity

T2 - consequences for the heterologous effects of BCG vaccination

AU - Kleinnijenhuis, Johanneke

AU - van Crevel, Reinout

AU - Netea, Mihai G.

PY - 2015/1

Y1 - 2015/1

N2 - A growing body of evidence from epidemiologic and immunologic studies have shown that in addition to target disease-specific effects, vaccines have heterologous effects towards unrelated pathogens. Like some other vaccines, bacille Calmette-Guerin (BCG) has shown in observational studies and randomized clinical trials to increase survival beyond the disease burden of the target disease. The immunologic substrate for these non-specific protective effects have been ascertained to heterologous T cell effects on the one hand, and to priming of innate immunity on the other hand. The term 'trained immunity' has been proposed to describe these potentiating effects of vaccines on innate immune responses. This process can explain the rapid effects of BCG vaccination and has been suggested to be mediated by epigenetic programming of monocytes or macrophages. This novel concept has important implications for the possible use of vaccines, for vaccination policy and even for the design of novel immunotherapeutic approaches.

AB - A growing body of evidence from epidemiologic and immunologic studies have shown that in addition to target disease-specific effects, vaccines have heterologous effects towards unrelated pathogens. Like some other vaccines, bacille Calmette-Guerin (BCG) has shown in observational studies and randomized clinical trials to increase survival beyond the disease burden of the target disease. The immunologic substrate for these non-specific protective effects have been ascertained to heterologous T cell effects on the one hand, and to priming of innate immunity on the other hand. The term 'trained immunity' has been proposed to describe these potentiating effects of vaccines on innate immune responses. This process can explain the rapid effects of BCG vaccination and has been suggested to be mediated by epigenetic programming of monocytes or macrophages. This novel concept has important implications for the possible use of vaccines, for vaccination policy and even for the design of novel immunotherapeutic approaches.

KW - BCG

KW - Innate immunity

KW - Heterologous effects

KW - Trained immunity

KW - Vaccine

KW - BACILLUS-CALMETTE-GUERIN

KW - SUPERFICIAL BLADDER-CANCER

KW - MALIGNANT-MELANOMA

KW - RANDOMIZED-TRIAL

KW - MYCOBACTERIUM-TUBERCULOSIS

KW - ACTIVATED MACROPHAGES

KW - CHILD-MORTALITY

KW - MEASLES-VACCINE

KW - GUINEA-BISSAU

KW - IMMUNOTHERAPY

U2 - 10.1093/trstmh/tru168

DO - 10.1093/trstmh/tru168

M3 - Review article

VL - 109

SP - 29

EP - 35

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 1

ER -

ID: 36676582