Publication

Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus

de Leeuw, K., Freire, B., Srnit, A. J., Bootsma, H., Kallenberg, C. G. & Bijl, M., 2006, In : Lupus. 15, 10, p. 675-682 8 p.

Research output: Contribution to journalArticleAcademicpeer-review

To determine risk factors of accelerated atherosclerosis in patients with systemic lupus erythematosus (SLE), 72 patients with inactive disease and 36 age- and sex-matched controls were included. The intima-media thickness (IMT) of the common carotid artery was determined by ultrasound. Traditional risk factors and disease-related factors were recorded. Cardiovascular risk was estimated using SCORE (systematic coronary risk evaluation). Markers of inflammation, endothelial activation and vascular remodelling (matrix metalloproteinases (MMP-3, MMP-9) and tissue inhibitor of metal loproteinase-1 (TIMP-1)) were determined.

IMT was increased in patients (0.67 mm +/- 0. 13 versus 0.61 min 0. 11, P <0.05). Prevalence of hypertension (33% versus 6%, P <0.001), SCORE (2.2 (1.7-4.2) versus 1.7 (1.3-2. 1), P <0.001), as well as parameters of inflammation (CRP 1.8 (0.6-5.8) mg/L versus 0.6 (0.2-1.0) mg/L, P <0.001) and endothelial activation (VCAM-I 505 (389-683) ng/mL versus 374 (322-427) ng/mL, P <0.001) and von Willebrand factor (138 (59-208)% versus 48 (24-92)%, P <0.001), were increased in patients. Vascular remodelling was altered: MMP-3 and TIMP-1 were increased (18 (10-29) ng/mL versus 8 (5-11) ng/mL, P <0.001, and 275 (216-352) ng/mL versus 230 (197-268) ng/mL, P <0.001, respectively), and MMP-9 was decreased in SLE (266 (147-412) ng/mL versus 348 (226-530) ng/mL, P <0.05).

Univariate analyses revealed that in patients IMT was associated with age, systolic blood pressure, SCORE and disease duration. In multivariate analysis, age and SCORE were independent predictors of IMT.

In conclusion, SLE patients have an increased IMT, which is associated with traditional risk factors. Non-traditional risk factors, such as endothelial activation, altered vascular remodelling and disease duration, might play an additional role.

Original languageEnglish
Pages (from-to)675-682
Number of pages8
JournalLupus
Volume15
Issue number10
Publication statusPublished - 2006

    Keywords

  • atherosclerosis, risk factors, systemic lupus erythematosus, INTIMA-MEDIA THICKNESS, B-MODE ULTRASOUND, CAROTID-ARTERY, DISEASE-ACTIVITY, ANTIPHOSPHOLIPID ANTIBODIES, CARDIOVASCULAR-DISEASE, VASCULAR-DISEASE, WOMEN, INDEX, PREVALENCE

ID: 1521454