Tracer application in cardiovascular imaging: a Triple Jump, Chapter 7: In: Autonomic Innervation of the Heart, Edited by R.H.J.A. Slart, R.A. Tio, P.H. Elsinga and M. Schwaiger

de Roo, F. M., Hilgerink, K., Kosterink, J., Luurtsema, G., Woerdenbag, H. & Boersma, H., 1-Mar-2015, Autonomic Innervation of the Heart. Slart, R., Tio, R., Elsinga, P. & Schwaiger, M. (eds.). Heidelberg: Springer, p. 137-159 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Next to aspects related to the imaging techniques, the quality of the used cardiovascular tracer is of major importance to produce reliable images, leading to accurate diagnoses as well as outcome of research and imaging-correlated treatment. We have built up this chapter on cardiovascular imaging according to the athletic triple jump. Hop, step, and jump are used as metaphors for three subsequent steps in the application of cardiovascular tracers. First, hop addresses general aspects as well as selection criteria of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers for cardiac innervation, myocardial perfusion, and heart failure. Second, step is focusing on the kind of translational as well as good manufacturing practice (GMP) activities needed to produce a clinical grade tracer. Third, jump, in which the relationship between clinical implementation of a radiopharmaceutical and quality management and good clinical practice (GCP) is presented.
Original languageEnglish
Title of host publicationAutonomic Innervation of the Heart
EditorsRiemer Slart, Rene Tio, Philipus Elsinga, Markus Schwaiger
Place of PublicationHeidelberg
Number of pages22
ISBN (Print)978-3-662-45074-1
Publication statusPublished - 1-Mar-2015


  • GMP, tracer development, clinical trials, medical ethics

ID: 16887817