Publication

Towards stem-cell therapy in the endocrine pancreas

Gangaram-Panday, S. T., Faas, M. M. & de Vos, P., Apr-2007, In : TRENDS IN MOLECULAR MEDICINE. 13, 4, p. 164-173 10 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.

Original languageEnglish
Pages (from-to)164-173
Number of pages10
JournalTRENDS IN MOLECULAR MEDICINE
Volume13
Issue number4
Publication statusPublished - Apr-2007

    Keywords

  • INSULIN-PRODUCING CELLS, UMBILICAL-CORD BLOOD, NESTIN-POSITIVE PROGENITOR, POSTNATAL RAT PANCREAS, BONE-MARROW, IN-VITRO, BETA-CELLS, EPITHELIAL MONOLAYERS, DIABETES-MELLITUS, ISLET-CELL

ID: 4557925