Towards stem-cell therapy in the endocrine pancreasGangaram-Panday, S. T., Faas, M. M. & de Vos, P., Apr-2007, In : TRENDS IN MOLECULAR MEDICINE. 13, 4, p. 164-173 10 p.
Research output: Contribution to journal › Review article › Academic › peer-review
Many approaches of stem-cell therapy for the treatment of diabetes have been described. One is the application of stem cells for replacement of nonfunctional islet cells in the native endogenous pancreas; another one is the use of stem cells as an inexhaustible source for islet-cell transplantation. During recent years three types of stem cells have been investigated: embryonic stem cells, bone-marrow-derived stem cells and organ-bound stem cells. We discuss the advantages and limitations of these different cell types. The applicability for the treatment of dysfunction of 0 cells in the pancreas has been demonstrated for all three cell types, but more-detailed understanding of the sequence of events during differentiation is required to produce fully functional insulin-producing cells.
|Number of pages||10|
|Journal||TRENDS IN MOLECULAR MEDICINE|
|Publication status||Published - Apr-2007|
- INSULIN-PRODUCING CELLS, UMBILICAL-CORD BLOOD, NESTIN-POSITIVE PROGENITOR, POSTNATAL RAT PANCREAS, BONE-MARROW, IN-VITRO, BETA-CELLS, EPITHELIAL MONOLAYERS, DIABETES-MELLITUS, ISLET-CELL