Publication

Towards prevention of AF progression

Hobbelt, A., 2019, [Groningen]: Rijksuniversiteit Groningen. 146 p.

Research output: ThesisThesis fully internal (DIV)Academic

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  • Title and contents

    Final publisher's version, 2 MB, PDF document

  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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  • Chapter 5

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  • Chapter 6

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  • Chapter 7

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  • Chapter 8

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  • Appendices

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  • Complete thesis

    Final publisher's version, 12 MB, PDF document

  • Propositions

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  • Anne Hobbelt
Structural changes of the atrial myocardium (remodeling) seems to play an important role in the incidence en perpetuation of atrial fibrillation. The presence of underlying diseases such as hypertension, heart failure, and increasing age are important contributors in this remodeling process. Previous studies have shown that early intervention and treatment of underlying risk factors might slow down the remodeling process. In the RACE 3 study we investigated whether risk factor driven upstream therapy is effective in patients with atrial fibrillation and leads to sinus rhythm maintenance. We showed that upstream therapy leads to better treatment of underlying risk factors such as hypertension and cholesterol, and sinus rhythm maintenance after one year compared to patients treated with conventional therapy. Furthermore we investigated differences in coagulation activity between very low risk young atrial fibrillation patients and healthy controls. We showed that those low risk patients with atrial fibrillation already had higher levels of the clotting factor IXa-antithrombin, which can be interpreted as a first signal of hypercoagulability. Additionally we showed that different atrial fibrillation patterns are associated with different underlying risk factors.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date24-Apr-2019
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-6361-231-9
Publication statusPublished - 2019

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