Publication

Towards open-ended evolution in self-replicating molecular systems

Duim, H. & Otto, S., 21-Jun-2017, In : Beilstein Journal of Organic Chemistry. 13, p. 1189-1203 15 p.

Research output: Contribution to journalReview articleAcademicpeer-review

APA

Duim, H., & Otto, S. (2017). Towards open-ended evolution in self-replicating molecular systems. Beilstein Journal of Organic Chemistry, 13, 1189-1203. https://doi.org/10.3762/bjoc.13.118

Author

Duim, Herman ; Otto, Sijbren. / Towards open-ended evolution in self-replicating molecular systems. In: Beilstein Journal of Organic Chemistry. 2017 ; Vol. 13. pp. 1189-1203.

Harvard

Duim, H & Otto, S 2017, 'Towards open-ended evolution in self-replicating molecular systems', Beilstein Journal of Organic Chemistry, vol. 13, pp. 1189-1203. https://doi.org/10.3762/bjoc.13.118

Standard

Towards open-ended evolution in self-replicating molecular systems. / Duim, Herman; Otto, Sijbren.

In: Beilstein Journal of Organic Chemistry, Vol. 13, 21.06.2017, p. 1189-1203.

Research output: Contribution to journalReview articleAcademicpeer-review

Vancouver

Duim H, Otto S. Towards open-ended evolution in self-replicating molecular systems. Beilstein Journal of Organic Chemistry. 2017 Jun 21;13:1189-1203. https://doi.org/10.3762/bjoc.13.118


BibTeX

@article{34c6da2d4f83491e9fd2181c6c7f24d1,
title = "Towards open-ended evolution in self-replicating molecular systems",
abstract = "In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.",
keywords = "autocatalysis, open-ended evolution, origin of life, self-replication, synthetic life, EXPONENTIAL-GROWTH, DIRECTED EVOLUTION, ERROR CATASTROPHE, RNA REPLICATORS, LIFE, SELECTION, PERSPECTIVES, COEXISTENCE, ORIGINS, PEPTIDE",
author = "Herman Duim and Sijbren Otto",
year = "2017",
month = "6",
day = "21",
doi = "10.3762/bjoc.13.118",
language = "English",
volume = "13",
pages = "1189--1203",
journal = "Beilstein Journal of Organic Chemistry",
issn = "1860-5397",
publisher = "BEILSTEIN-INSTITUT",

}

RIS

TY - JOUR

T1 - Towards open-ended evolution in self-replicating molecular systems

AU - Duim, Herman

AU - Otto, Sijbren

PY - 2017/6/21

Y1 - 2017/6/21

N2 - In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.

AB - In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.

KW - autocatalysis

KW - open-ended evolution

KW - origin of life

KW - self-replication

KW - synthetic life

KW - EXPONENTIAL-GROWTH

KW - DIRECTED EVOLUTION

KW - ERROR CATASTROPHE

KW - RNA REPLICATORS

KW - LIFE

KW - SELECTION

KW - PERSPECTIVES

KW - COEXISTENCE

KW - ORIGINS

KW - PEPTIDE

U2 - 10.3762/bjoc.13.118

DO - 10.3762/bjoc.13.118

M3 - Review article

VL - 13

SP - 1189

EP - 1203

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

SN - 1860-5397

ER -

ID: 49203825