Publication

Towards improved and broadly protective influenza vaccines: Focus on delivery systems, routes of administration and animal models

Bhide, Y., 2018, [Groningen]: Rijksuniversiteit Groningen. 187 p.

Research output: ThesisThesis fully internal (DIV)Academic

Copy link to clipboard

Documents

  • Title and contents

    Final publisher's version, 507 KB, PDF document

  • Chapter 1

    Final publisher's version, 1 MB, PDF document

  • Chapter 2

    Final publisher's version, 2 MB, PDF document

  • Chapter 3

    Final publisher's version, 1 MB, PDF document

  • Chapter 4

    Final publisher's version, 1 MB, PDF document

  • Chapter 5

    Final publisher's version, 964 KB, PDF document

  • Chapter 6

    Final publisher's version, 1 MB, PDF document

  • Chapter 7

    Final publisher's version, 500 KB, PDF document

  • Appendices

    Final publisher's version, 128 KB, PDF document

  • Complete thesis

    Final publisher's version, 8 MB, PDF document

  • Propositions

    Final publisher's version, 175 KB, PDF document

Influenza is one of the major respiratory infections and is associated with high disease burden globally. Vaccination is the foundation for influenza control. However, current influenza vaccines provide protection only against virus strains that are part of the vaccine. This is a serious problem since the influenza virus changes from year to year and occasionally completely new virus strains enter the human population. Accordingly, influenza vaccines need to be reformulated each year to match the virus strains presumably circulating in the particular season and even then cannot protect against newly emerging virus strains. A broadly protective influenza vaccine could overcome these problems and would thus be highly desirable to protect against future epidemics and pandemics.
In this thesis we tested several approaches and strategies in order to find out how protection against a broad range of influenza virus strains could be achieved. Focus of the work was on the elucidation of the role of different immune mechanisms in protection from infection. We found that immunization via the airways was more effective than immunization via traditional intramuscular injection. Giving two sequential immunizations with inactivated viruses from different virus strains appeared to be a simple and suitable strategy to provide protection against new virus strains.
Our research, performed in the context of the EU-financed consortium UNISEC (Universal Influenza Vaccines Secured), provides guidance for the development of new generation influenza vaccines with improved efficacy and breadth of protection.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
Award date8-Oct-2018
Place of Publication[Groningen]
Publisher
Print ISBNs978-94-6375-131-5
Publication statusPublished - 2018

Download statistics

No data available

ID: 64971270