Publication

Towards an antimicrobial 'microglove'

Reilman, E., Hagting, J. G., Flipsen, T., Ulmer, H. & van Dijl, J. M., 13-Nov-2015, In : Scientific Reports. 5, 11 p., 16679.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Reilman, E., Hagting, J. G., Flipsen, T., Ulmer, H., & van Dijl, J. M. (2015). Towards an antimicrobial 'microglove'. Scientific Reports, 5, [16679]. https://doi.org/10.1038/srep16679

Author

Reilman, Ewoud ; Hagting, Joke G. ; Flipsen, Theo ; Ulmer, Herb ; van Dijl, Jan Maarten. / Towards an antimicrobial 'microglove'. In: Scientific Reports. 2015 ; Vol. 5.

Harvard

Reilman, E, Hagting, JG, Flipsen, T, Ulmer, H & van Dijl, JM 2015, 'Towards an antimicrobial 'microglove'' Scientific Reports, vol. 5, 16679. https://doi.org/10.1038/srep16679

Standard

Towards an antimicrobial 'microglove'. / Reilman, Ewoud; Hagting, Joke G.; Flipsen, Theo; Ulmer, Herb; van Dijl, Jan Maarten.

In: Scientific Reports, Vol. 5, 16679, 13.11.2015.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Reilman E, Hagting JG, Flipsen T, Ulmer H, van Dijl JM. Towards an antimicrobial 'microglove'. Scientific Reports. 2015 Nov 13;5. 16679. https://doi.org/10.1038/srep16679


BibTeX

@article{1bf14a860103411e83357cf051fbc43a,
title = "Towards an antimicrobial 'microglove'",
abstract = "A large proportion of hospital-related infections are acquired and spread due to the direct contacts between patients and healthcare workers. Accordingly, proper infection prevention measures, and especially hand hygiene, are key to limit the spread of infections in nosocomial settings. However, healthcare workers frequently experience difficulties in complying strictly to hand disinfection protocols. This study was therefore aimed at the development of a hand rub with antimicrobial activity that forms a protective film on the hand, a so-called microglove, in order to enhance hand hygiene. For this purpose, various co-polymer formulations consisting of different ratios of Polyvinylpyrrolidone (PVP) and a branched C20 derivatized maleate (M20) in combination with the known biocide benzalkonium chloride (BKC) were tested for their combined film-forming and antimicrobial activities. The results of a series of novel contamination and transmission assays show that a formulation of 80{\%} PVP and 20{\%} M20 co-polymer with 0.9{\%} BKC fulfils the elementary requirements for an antimicrobial microglove.",
keywords = "STAPHYLOCOCCUS-AUREUS, PATIENT-CARE, INFECTIONS, RESISTANCE, PREVENTION, HOSPITALS, SALTS, RISK",
author = "Ewoud Reilman and Hagting, {Joke G.} and Theo Flipsen and Herb Ulmer and {van Dijl}, {Jan Maarten}",
year = "2015",
month = "11",
day = "13",
doi = "10.1038/srep16679",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Towards an antimicrobial 'microglove'

AU - Reilman, Ewoud

AU - Hagting, Joke G.

AU - Flipsen, Theo

AU - Ulmer, Herb

AU - van Dijl, Jan Maarten

PY - 2015/11/13

Y1 - 2015/11/13

N2 - A large proportion of hospital-related infections are acquired and spread due to the direct contacts between patients and healthcare workers. Accordingly, proper infection prevention measures, and especially hand hygiene, are key to limit the spread of infections in nosocomial settings. However, healthcare workers frequently experience difficulties in complying strictly to hand disinfection protocols. This study was therefore aimed at the development of a hand rub with antimicrobial activity that forms a protective film on the hand, a so-called microglove, in order to enhance hand hygiene. For this purpose, various co-polymer formulations consisting of different ratios of Polyvinylpyrrolidone (PVP) and a branched C20 derivatized maleate (M20) in combination with the known biocide benzalkonium chloride (BKC) were tested for their combined film-forming and antimicrobial activities. The results of a series of novel contamination and transmission assays show that a formulation of 80% PVP and 20% M20 co-polymer with 0.9% BKC fulfils the elementary requirements for an antimicrobial microglove.

AB - A large proportion of hospital-related infections are acquired and spread due to the direct contacts between patients and healthcare workers. Accordingly, proper infection prevention measures, and especially hand hygiene, are key to limit the spread of infections in nosocomial settings. However, healthcare workers frequently experience difficulties in complying strictly to hand disinfection protocols. This study was therefore aimed at the development of a hand rub with antimicrobial activity that forms a protective film on the hand, a so-called microglove, in order to enhance hand hygiene. For this purpose, various co-polymer formulations consisting of different ratios of Polyvinylpyrrolidone (PVP) and a branched C20 derivatized maleate (M20) in combination with the known biocide benzalkonium chloride (BKC) were tested for their combined film-forming and antimicrobial activities. The results of a series of novel contamination and transmission assays show that a formulation of 80% PVP and 20% M20 co-polymer with 0.9% BKC fulfils the elementary requirements for an antimicrobial microglove.

KW - STAPHYLOCOCCUS-AUREUS

KW - PATIENT-CARE

KW - INFECTIONS

KW - RESISTANCE

KW - PREVENTION

KW - HOSPITALS

KW - SALTS

KW - RISK

U2 - 10.1038/srep16679

DO - 10.1038/srep16679

M3 - Article

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 16679

ER -

ID: 26628152