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Toward Using Fluorescent Nanodiamonds To Study Chronological Aging in Saccharomyces cerevisiae
van der Laan, K., Naulleau, J., Damle, V. G., Sigaeva, A., Jamot, N., Perona Martinez, F. P., Chipaux, M. & Schirhagl, R., 20-Nov-2018, In : Analytical Chemistry. 90, 22, p. 13506-13513 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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Toward Using Fluorescent Nanodiamonds To Study Chronological Aging in Saccharomyces cerevisiae. / van der Laan, Kiran; Naulleau, Julie; Damle, Viraj G; Sigaeva, Alina; Jamot, Nicolas; Perona Martinez, Felipe P; Chipaux, Mayeul; Schirhagl, Romana.
In: Analytical Chemistry, Vol. 90, No. 22, 20.11.2018, p. 13506-13513.Research output: Contribution to journal › Article › Academic › peer-review
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TY - JOUR
T1 - Toward Using Fluorescent Nanodiamonds To Study Chronological Aging in Saccharomyces cerevisiae
AU - van der Laan, Kiran
AU - Naulleau, Julie
AU - Damle, Viraj G
AU - Sigaeva, Alina
AU - Jamot, Nicolas
AU - Perona Martinez, Felipe P
AU - Chipaux, Mayeul
AU - Schirhagl, Romana
PY - 2018/11/20
Y1 - 2018/11/20
N2 - One of the theories aiming to explain cellular aging is the free radical theory of aging, which describes the possible role of increased production and accumulation of free radicals. Fluorescent nanodiamonds (FNDs) are proposed to provide a tool to detect these radicals, as they function as magnetic sensors that change their optical properties depending on their magnetic surrounding. Therefore, they could enable the study of aging at a molecular level and unravel the exact role of free radicals in this process. In this study, important steps toward this goal are made. FNDs are introduced in chronologically aging yeast cells. Furthermore, the behavior of FNDs in these aging cells is studied to demonstrate the potency of using FNDs in the search for causes of cellular aging.
AB - One of the theories aiming to explain cellular aging is the free radical theory of aging, which describes the possible role of increased production and accumulation of free radicals. Fluorescent nanodiamonds (FNDs) are proposed to provide a tool to detect these radicals, as they function as magnetic sensors that change their optical properties depending on their magnetic surrounding. Therefore, they could enable the study of aging at a molecular level and unravel the exact role of free radicals in this process. In this study, important steps toward this goal are made. FNDs are introduced in chronologically aging yeast cells. Furthermore, the behavior of FNDs in these aging cells is studied to demonstrate the potency of using FNDs in the search for causes of cellular aging.
KW - YEAST
KW - TRACKING
KW - MODEL
U2 - 10.1021/acs.analchem.8b03431
DO - 10.1021/acs.analchem.8b03431
M3 - Article
C2 - 30345733
VL - 90
SP - 13506
EP - 13513
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 22
ER -
ID: 66763145