Publication

TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: Clinical and experimental considerations

Huugen, D., Tervaert, J. W. C. & Heeringa, P., Sep-2006, In : Journal of the American Society of Nephrology. 1, 5, p. 1100-1107 8 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Wegener's granulomatosis, microscopic polyangiitis, idiopathic necrotizing crescentic glomerulonephritis, and Churg-Strauss syndrome are associated with the presence of ANCA with specificity for myeloperoxidase or proteinase 3. Current therapy consists mainly of corticosteroids and cyclophosphamide, but because this treatment regimen is associated with considerable morbidity, other treatment modalities remain desirable. There is compelling evidence that TNF-alpha plays an important role in the pathogenesis of ANCA-associated vasculitis. Consequently, inhibition of TNF-alpha bioactivity potentially results in attenuation of disease. This review discusses whether TNF-alpha bioactivity-inhibiting drugs are useful in the treatment of ANCA-associated vasculitis. The results of in vitro and in vivo experiments, as well as clinical studies, are evaluated. Although the importance of TNF-alpha during lesion development is evident, clinical trials that use TNF-alpha blockers in patients with ANCA-associated vasculitis give mixed results. Importantly, in a large-scale, randomized trial, treatment with etanercept was found not to be effective and resulted in an excess of treatment-related morbidity. It remains to be investigated whether inhibition of TNF-alpha bioactivity is effective in a subgroup of patients.

Original languageEnglish
Pages (from-to)1100-1107
Number of pages8
JournalJournal of the American Society of Nephrology
Volume1
Issue number5
Publication statusPublished - Sep-2006

    Keywords

  • TUMOR-NECROSIS-FACTOR, ANTINEUTROPHIL-CYTOPLASMIC ANTIBODIES, EXPERIMENTAL CRESCENTIC GLOMERULONEPHRITIS, RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS, REFRACTORY WEGENERS-GRANULOMATOSIS, ACTIVE RHEUMATOID-ARTHRITIS, CROHNS-DISEASE, ANKYLOSING-SPONDYLITIS, SYSTEMIC VASCULITIS, MONOCLONAL-ANTIBODY

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