Publication

Thrombolysis for Acute Ischemic Stroke

Uyttenboogaart, M., De Keyser, J. & Luijckx, G. J., Oct-2009, In : Current topics in medicinal chemistry. 9, 14, p. 1285-1290 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

In the last decennium, thrombolytic therapy has changed the management of acute ischemic stroke. Randomized clinical studies have demonstrated that intravenous thrombolysis with tissue plasminogen activator improves functional outcomes. Recently the time window for intravenous thrombolysis has been extended from 3 to 4.5 hours after stroke onset, which will allow more stroke patients to benefit from this treatment. Currently several studies are investigating how to improve recanalization rates of thrombolytic therapy. In this review several aspects of intravenous and intra-arterial thrombolysis are discussed.

Original languageEnglish
Pages (from-to)1285-1290
Number of pages6
JournalCurrent topics in medicinal chemistry
Volume9
Issue number14
Publication statusPublished - Oct-2009

    Keywords

  • TISSUE-PLASMINOGEN ACTIVATOR, RANDOMIZED CONTROLLED-TRIAL, CEREBRAL-ARTERY STROKE, INTRAVENOUS THROMBOLYSIS, TIME WINDOW, INTERVENTIONAL MANAGEMENT, INTRACEREBRAL HEMORRHAGE, TPA THERAPY, 3 H, ALTEPLASE

ID: 5000670