Publication

Therapeutic options for patients with advanced atrial fibrillation: from lifestyle and medication to catheter and surgical ablation

Boersma, L., Rienstra, M. & de Groot, J. R., 11-Aug-2020, In : Netherlands Heart Journal. 28, SUPPL 1, p. 13-18 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Atrial fibrillation (AF) is part of a vicious cycle that includes multiple cardiovascular risk factors and comorbidity which can promote atrial remodelling and AF progression. Most AF-related risk factors-hypertension, diabetes, sleep apnoea, obesity and sedentary lifestyle-are in essence modifiable which may prevent AF development. Treatment of associated cardiovascular conditions may prevent both symptoms and future cardiovascular events. For advanced forms of symptomatic AF refractory to lifestyle management and optimal medication, invasive ablation therapies have become a cornerstone. Although electrical trigger isolation from the pulmonary veins is reasonably effective and safe, more potent energy sources including high output-short duration radiofrequency, ultra-low cryo-energy, and electroporation, as well as more sophisticated arrays, balloons, and lattice-tipped catheter tools, are on their way to eliminate existing pitfalls and simplify the procedure. Electroanatomical navigation and mapping systems are becoming available to provide real-time information on ablation lesion quality and the critical pathways of AF in the individual patient to guide more extensive ablation strategies that may enhance long-term outcome for freedom of advanced AF. Surgical techniques, either stand-alone or concomitant to structural cardiac repair, hybrid, or convergent, with novel less invasive access options are developing and can be helpful in situations unsuitable for catheter ablation.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalNetherlands Heart Journal
Volume28
Issue numberSUPPL 1
Publication statusPublished - 11-Aug-2020

    Keywords

  • Atrial fibrillation, Upstream therapy, Catheter ablation, Surgical ablation, Lifestyle, PULMONARY VEIN ISOLATION, PHYSICAL-ACTIVITY, RADIOFREQUENCY ABLATION, PLEXUS ABLATION, HEART-FAILURE, RISK-FACTORS, MANAGEMENT, CRYOBALLOON, ARRHYTHMIAS, PREVALENCE

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