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Therapeutic approach to pain in neurodegenerative diseases: current evidence and perspectives

de Tommaso, M., Kunz, M. & Valeriani, M., Feb-2017, In : Expert review of neurotherapeutics. 17, 2, p. 143-153 11 p.

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  • Therapeutic approach to pain in neurodegenerative

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Introduction: Neurodegenerative diseases are increasing in parallel to the lengthening of survival. The management of Alzheimer's disease (AD) and other dementias, Parkinson's disease (PD) and PD-related disorders, and motor neuron diseases (MND), is mainly targeted to motor and cognitive impairment, with special care for vital functions such as breathing and feeding.Areas covered: The present review focuses on chronic pain in main neurodegenerative diseases, addressing current evidence on pain therapeutic management, pain frequency and clinical features, and possible pathophysiological mechanisms. The search on PubMed had no time limits and was performed by searching for the following key issues: pain, dementia, Alzheimer disease, Parkinson's disease, extrapyramidal disorders, motoneuronal disease, Amyotrophic lateral sclerosis, FXTAS, frequency, pathophysiology, treatments, therapy, efficacy, opioids, side effects. No controlled therapeutic trials and guidelines are currently available. The effects of current therapies such as L-Dopa or riluzole on pain symptoms are not clear. Emerging evidences on the possible anti-nociceptive effects of cannabis or botulinum toxin might be available soon.Expert commentary: Pain needs to be better evaluated and fully considered in the global management of neurodegenerative disease because a more focused treatment may have a positive impact on the global burden of these devastating disorders.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalExpert review of neurotherapeutics
Volume17
Issue number2
Publication statusPublished - Feb-2017

    Keywords

  • Alzheimer's disease, Parkinson's diseases, amyotrophic lateral sclerosis, pain frequency, clinical features, current treatment, AMYOTROPHIC-LATERAL-SCLEROSIS, NURSING-HOME RESIDENTS, LASER-EVOKED-POTENTIALS, SMALL-FIBER NEUROPATHY, PROLONGED-RELEASE OXYCODONE, MULTIPLE SYSTEM ATROPHY, MOTOR-NEURON DISEASE, PARKINSONS-DISEASE, SPASMODIC TORTICOLLIS, CERVICAL DYSTONIA

ID: 33600690