Publication

The YidC/Oxa1/Alb3 protein family: common principles and distinct features

Saller, M. J., Wu, Z. C., de Keyzer, J. & Driessen, A. J. M., Nov-2012, In : Biological Chemistry. 393, 11, p. 1279-1290 12 p.

Research output: Contribution to journalReview articleAcademicpeer-review

The members of the YidC/Oxa1/Alb3 protein family are evolutionary conserved in all three domains of life. They facilitate the insertion of membrane proteins into bacterial, mitochondrial, and thylakoid membranes and have been implicated in membrane protein folding and complex formation. The major classes of substrates are small hydrophobic subunits of large energy-transducing complexes involved in respiration and light capturing. All YidC-like proteins share a conserved membrane region, whereas the N- and C-terminal regions are diverse and fulfill accessory functions in protein targeting.

Original languageEnglish
Pages (from-to)1279-1290
Number of pages12
JournalBiological Chemistry
Volume393
Issue number11
Publication statusPublished - Nov-2012

    Keywords

  • bacteria, biogenesis, membrane protein insertion, mitochondria, targeting, thylakoids, SIGNAL RECOGNITION PARTICLE, ESCHERICHIA-COLI YIDC, PF3 COAT PROTEIN, INNER MEMBRANE-PROTEINS, INDEPENDENT GENE DUPLICATIONS, SACCHAROMYCES-CEREVISIAE, CYTOCHROME-OXIDASE, PERIPLASMIC DOMAIN, BACILLUS-SUBTILIS, SUBUNIT-C

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