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The vascular nature of COVID-19

Oudkerk, M., Kuijpers, D., Oudkerk, S. F. & van Beek, E. J., 2020, In : British journal of radiology. 93, 1113, p. 20200718 3 p., 20200718.

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A potential link between mortality, D-dimer values and a prothrombotic syndrome has been reported in COVID-19 patients. The National Institute for Public Health of the Netherlands published a report for guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19 with a new vascular disease concept. The analysis of all available current medical, laboratory and imaging data on COVID-19 confirms that symptoms and diagnostic tests can not be explained by impaired pulmonary ventilation. Further imaging and pathological investigations confirm that the COVID-19 syndrome is explained by perfusion disturbances first in the lung, but consecutively in all organs of the body. Damage of the microvasculature by SARS 1 and SARS 2 (COVID-19) viruses causes microthrombotic changes in the pulmonary capillaries and organs leading to macrothrombosis and emboli. Therefore anticoagulant profylaxis, close lab and CT imaging monitoring and early anticoagulant therapy are indicated.

Original languageEnglish
Article number20200718
Pages (from-to)20200718
Number of pages3
JournalBritish journal of radiology
Volume93
Issue number1113
Early online date31-Jul-2020
Publication statusPublished - 2020

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