Publication

The two-process model: Origin and perspective

Daan, S., Hut, R. A. & Beersma, D., Sep-2014, In : Journal of Sleep Research. 23, p. 21-21 1 p.

Research output: Contribution to journalMeeting AbstractAcademic

In the two-process model as developed in the early 1980's sleep is controlled by a process-S, representing the rise and fall of sleep demand resulting from prior sleep-wake history, interacting with a process-C representing circadian variation in sleep propensity. S and C together optimize sleep timing and intensity with respect to internal demand and external opportunity. The theoretical distinction between S and C has been useful in understanding many aspects of sleep, most prominently 'internal desynchronization' and circadian vs. homeostatic aspects of physiology. Both S and C concepts met difficulties as they were further explored in mathematical detail. The simple S dynamics of the model became problematic when SWA dynamics appeared to vary between brain areas. The C process was originally identified with the circadian pacemaker in the SCN. Some researchers even specifically attributed the direct control of activity and rest to the SCN. Yet, activity-rest rhythms under special circumstances (feeding schedules; methamphetamine) turned out to require neither the SCN nor circadian clock genes, and have an oscillatory basis themselves. Recent studies show that in animals the activity-rest cycle adaptively shifts from night to day under metabolic influence. The SCN itself remains rigidly tied to the day and night outside, acting as a clock entraining, not dictating other circadian processes. The original S-C model provides a basic framework for the much needed analysis of the role of metabolism in the temporal organisation of sleep and wake. It will require adjustment, not abandonment.
Original languageEnglish
Pages (from-to)21-21
Number of pages1
JournalJournal of Sleep Research
Volume23
Publication statusPublished - Sep-2014
Event22nd Congress of the European Sleep Research Society - Tallinn, Estonia
Duration: 16-Sep-201420-Sep-2014

Event

22nd Congress of the European Sleep Research Society

16/09/201420/09/2014

Tallinn, Estonia

Event: Conference

    Keywords

  • methamphetamine, process model, sleep, society, model, circadian rhythm, night, dynamics, scientist, pacemaker, human, metabolism, feeding, gene, rhythm, brain, physiology

ID: 23334325