The twisted relation between Pnu and SWEET transportersJähme, M., Guskov, A. & Slotboom, D., 7-Mar-2015, In : Trends in Biochemical Sciences. 40, 4, p. 183-188 6 p.
Research output: Contribution to journal › Article › Academic › peer-review
The evolutionary relation between sugar and vitamin transporters from the SWEET and Pnu families is un- clear. They have similar 3D structures, but differ in the topology of their secondary structure elements, and lack significant sequence similarity. Here we analyze the structures and sequences of different members of the SWEET and Pnu transporter families and propose an evolutionary pathway by which they may have diverged from a common ancestor. A 3D domain swapping event can explain the topological differences between the families, as well as the puzzling observation that a highly conserved and essential sequence motif of the SWEET family (the PQ loop) is absent from the Pnu transporters
|Number of pages||6|
|Journal||Trends in Biochemical Sciences|
|Publication status||Published - 7-Mar-2015|