The temporal dynamics of the stress response

Koolhaas, J. M., Meerlo, P., de Boer, S. F., Strubbe, J. H. & Bohus, B. G. J., 1997, In : Neuroscience and Biobehavioral Reviews. 21, 6, p. 775-782 8 p.

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This paper summarises the available evidence that failure of defense mechanisms in (semi)-natural social groups of animals may lead to serious forms of stress pathology. Hence the study of social stress may provide animal models with a high face validity. However, most of the animal models of human stress-disorders have concentrated on the consequences of chronic exposure to stressors. The present paper considers recent data, indicating that a single experience with a major stressor in the form of social defeat may have long-term consequences ranging from hours to days and weeks. It seems that the experience of a major stressor sensitizes the animal to subsequent stressors. The consequences of these long-term temporal dynamics of the stress response to the development of stress-related disorders and stress-vulnerability are discussed. (C) 1997 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)775-782
Number of pages8
JournalNeuroscience and Biobehavioral Reviews
Issue number6
Publication statusPublished - 1997


  • stress, stress response, stressor, stress pathology, psychopathology, depression, animal models, social stress, social defeat, temporal dynamics, stress sensitization, corticosterone

ID: 853506