Publication

The systemic impact of a surgical procedure in older oncological patients

Plas, M., de Haan, J. J., van der Wal-Huisman, H., Rutgers, A., Absalom, A. R., de Bock, G. H. & van Leeuwen, B. L., Aug-2019, In : European Journal of Surgical Oncology. 45, 8, p. 1403-1409 7 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Plas, M., de Haan, J. J., van der Wal-Huisman, H., Rutgers, A., Absalom, A. R., de Bock, G. H., & van Leeuwen, B. L. (2019). The systemic impact of a surgical procedure in older oncological patients. European Journal of Surgical Oncology, 45(8), 1403-1409. https://doi.org/10.1016/j.ejso.2019.04.024

Author

Plas, Matthijs ; de Haan, Jacco J ; van der Wal-Huisman, Hanneke ; Rutgers, Abraham ; Absalom, Anthony R ; de Bock, Geertruida H ; van Leeuwen, Barbara L. / The systemic impact of a surgical procedure in older oncological patients. In: European Journal of Surgical Oncology. 2019 ; Vol. 45, No. 8. pp. 1403-1409.

Harvard

Plas, M, de Haan, JJ, van der Wal-Huisman, H, Rutgers, A, Absalom, AR, de Bock, GH & van Leeuwen, BL 2019, 'The systemic impact of a surgical procedure in older oncological patients', European Journal of Surgical Oncology, vol. 45, no. 8, pp. 1403-1409. https://doi.org/10.1016/j.ejso.2019.04.024

Standard

The systemic impact of a surgical procedure in older oncological patients. / Plas, Matthijs; de Haan, Jacco J; van der Wal-Huisman, Hanneke; Rutgers, Abraham; Absalom, Anthony R; de Bock, Geertruida H; van Leeuwen, Barbara L.

In: European Journal of Surgical Oncology, Vol. 45, No. 8, 08.2019, p. 1403-1409.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Plas M, de Haan JJ, van der Wal-Huisman H, Rutgers A, Absalom AR, de Bock GH et al. The systemic impact of a surgical procedure in older oncological patients. European Journal of Surgical Oncology. 2019 Aug;45(8):1403-1409. https://doi.org/10.1016/j.ejso.2019.04.024


BibTeX

@article{03e7bd0619c441f1afb0a37db867aabb,
title = "The systemic impact of a surgical procedure in older oncological patients",
abstract = "Background: An excessive inflammatory response accounts partially for the increased morbidity and mortality seen in elderly surgical patients. The aim of this study was to investigate the association between a range of pre- and peroperative factors and the extent of the inflammatory response, and to identify patients at risk of a greater inflammatory response following surgery.Methods: Patients 65 years and older undergoing a surgical procedure for a solid malignant tumour were prospectively included in an observational cohort study. Inflammatory markers were measured in plasma samples pre- and postoperatively: C-reactive protein (CRP), Interleukin-1 beta (IL-1 beta), IL-6, IL-10, IL-12, and Tumour necrosis factor alpha (TNF-alpha). Preoperative and postoperative inflammatory factor assay results were compared, and associations between inflammatory markers and pre- and peroperative factors were explored using multivariate linear regression analysis.Results: Between July 2010 and April 2014, plasma samples of 224 patients were obtained. Median age was 72 (65-89) years and 108 (48.2{\%}) patients were male. The predominant diagnosis was carcinoma, 156 (69.6{\%}). Anaesthesia duration was associated with increase in CRP, IL-1 beta and IL-6; intracavitary surgery with increase in IL-6; blood loss with decrease in CRP and IL-1 beta; total fluid volume administered with a decrease in IL-1 beta and disease stage was associated with increase in IL-6.Conclusions: The perioperative inflammatory response is related more to surgical characteristics rather than to preoperative factors (with the exception of disease stage). Elderly oncological patients undergoing longer lasting, intracavitary surgical procedures for more advanced disease stages develop the most intense inflammatory response. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.",
keywords = "Elderly, Surgical oncology, Inflammation, Cytokines, INFLAMMATORY RESPONSE, INTERLEUKIN-12 PRODUCTION, COGNITIVE DECLINE, OPEN SURGERY, CANCER, PERSPECTIVE, RESISTANCE, THERAPY, SEPSIS",
author = "Matthijs Plas and {de Haan}, {Jacco J} and {van der Wal-Huisman}, Hanneke and Abraham Rutgers and Absalom, {Anthony R} and {de Bock}, {Geertruida H} and {van Leeuwen}, {Barbara L}",
note = "Copyright {\circledC} 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.",
year = "2019",
month = "8",
doi = "10.1016/j.ejso.2019.04.024",
language = "English",
volume = "45",
pages = "1403--1409",
journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
publisher = "ELSEVIER SCI LTD",
number = "8",

}

RIS

TY - JOUR

T1 - The systemic impact of a surgical procedure in older oncological patients

AU - Plas, Matthijs

AU - de Haan, Jacco J

AU - van der Wal-Huisman, Hanneke

AU - Rutgers, Abraham

AU - Absalom, Anthony R

AU - de Bock, Geertruida H

AU - van Leeuwen, Barbara L

N1 - Copyright © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

PY - 2019/8

Y1 - 2019/8

N2 - Background: An excessive inflammatory response accounts partially for the increased morbidity and mortality seen in elderly surgical patients. The aim of this study was to investigate the association between a range of pre- and peroperative factors and the extent of the inflammatory response, and to identify patients at risk of a greater inflammatory response following surgery.Methods: Patients 65 years and older undergoing a surgical procedure for a solid malignant tumour were prospectively included in an observational cohort study. Inflammatory markers were measured in plasma samples pre- and postoperatively: C-reactive protein (CRP), Interleukin-1 beta (IL-1 beta), IL-6, IL-10, IL-12, and Tumour necrosis factor alpha (TNF-alpha). Preoperative and postoperative inflammatory factor assay results were compared, and associations between inflammatory markers and pre- and peroperative factors were explored using multivariate linear regression analysis.Results: Between July 2010 and April 2014, plasma samples of 224 patients were obtained. Median age was 72 (65-89) years and 108 (48.2%) patients were male. The predominant diagnosis was carcinoma, 156 (69.6%). Anaesthesia duration was associated with increase in CRP, IL-1 beta and IL-6; intracavitary surgery with increase in IL-6; blood loss with decrease in CRP and IL-1 beta; total fluid volume administered with a decrease in IL-1 beta and disease stage was associated with increase in IL-6.Conclusions: The perioperative inflammatory response is related more to surgical characteristics rather than to preoperative factors (with the exception of disease stage). Elderly oncological patients undergoing longer lasting, intracavitary surgical procedures for more advanced disease stages develop the most intense inflammatory response. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

AB - Background: An excessive inflammatory response accounts partially for the increased morbidity and mortality seen in elderly surgical patients. The aim of this study was to investigate the association between a range of pre- and peroperative factors and the extent of the inflammatory response, and to identify patients at risk of a greater inflammatory response following surgery.Methods: Patients 65 years and older undergoing a surgical procedure for a solid malignant tumour were prospectively included in an observational cohort study. Inflammatory markers were measured in plasma samples pre- and postoperatively: C-reactive protein (CRP), Interleukin-1 beta (IL-1 beta), IL-6, IL-10, IL-12, and Tumour necrosis factor alpha (TNF-alpha). Preoperative and postoperative inflammatory factor assay results were compared, and associations between inflammatory markers and pre- and peroperative factors were explored using multivariate linear regression analysis.Results: Between July 2010 and April 2014, plasma samples of 224 patients were obtained. Median age was 72 (65-89) years and 108 (48.2%) patients were male. The predominant diagnosis was carcinoma, 156 (69.6%). Anaesthesia duration was associated with increase in CRP, IL-1 beta and IL-6; intracavitary surgery with increase in IL-6; blood loss with decrease in CRP and IL-1 beta; total fluid volume administered with a decrease in IL-1 beta and disease stage was associated with increase in IL-6.Conclusions: The perioperative inflammatory response is related more to surgical characteristics rather than to preoperative factors (with the exception of disease stage). Elderly oncological patients undergoing longer lasting, intracavitary surgical procedures for more advanced disease stages develop the most intense inflammatory response. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

KW - Elderly

KW - Surgical oncology

KW - Inflammation

KW - Cytokines

KW - INFLAMMATORY RESPONSE

KW - INTERLEUKIN-12 PRODUCTION

KW - COGNITIVE DECLINE

KW - OPEN SURGERY

KW - CANCER

KW - PERSPECTIVE

KW - RESISTANCE

KW - THERAPY

KW - SEPSIS

U2 - 10.1016/j.ejso.2019.04.024

DO - 10.1016/j.ejso.2019.04.024

M3 - Article

VL - 45

SP - 1403

EP - 1409

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

IS - 8

ER -

ID: 83561707