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The Sulfolobicin Genes of Sulfolobus acidocaldarius Encode Novel Antimicrobial Proteins

Ellen, A. F., Rohulya, O. V., Fusetti, F., Wagner, M., Albers, S-V. & Driessen, A. J. M., Sep-2011, In : Journal of Bacteriology. 193, 17, p. 4380-4387 8 p.

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  • The Sulfolobicin Genes of Sulfolobus

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DOI

Crenarchaea, such as Sulfolobus acidocaldarius and Sulfolobus tokodaii, produce antimicrobial proteins called sulfolobicins. These antimicrobial proteins inhibit the growth of closely related species. Here we report the identification of the sulfolobicin-encoding genes in S. acidocaldarius. The active sulfolobicin comprises two proteins that are equipped with a classical signal sequence. These proteins are secreted by the cells and found to be membrane vesicle associated. Gene inactivation studies demonstrate that both proteins are required for the bacteriostatic antimicrobial activity. Sulfolobicins constitute a novel class of antimicrobial proteins without detectable homology to any other protein.

Original languageEnglish
Pages (from-to)4380-4387
Number of pages8
JournalJournal of Bacteriology
Volume193
Issue number17
Publication statusPublished - Sep-2011

    Keywords

  • HYPERTHERMOPHILIC ARCHAEON, MEMBRANE-VESICLES, GENUS SULFOLOBUS, COMPLETE GENOME, STRAIN AS7092, HALOCIN C8, BACTERIA, DNA, CRENARCHAEON, COMPONENTS

ID: 5382984