The sNIHSS-4 predicts outcome in right and left anterior circulation strokes

De Raedt, S., Brouns, R., De Smedt, A., Aries, M. J. H., Uyttenboogaart, M., Luijckx, G. J. & De Keyser, J., Jun-2013, In : Clinical neurology and neurosurgery. 115, 6, p. 729-731 3 p.

Research output: Contribution to journalArticleAcademicpeer-review

Background and purpose: Stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS) is a strong predictor of functional outcome.

A short version, the sNIHSS-5, scoring only strength in right and left leg, gaze, visual fields and language, was developed for use in the prehospital setting. Because scoring both legs in anterior circulation strokes is not contributive, we assessed the value of a 4-item score (the sNIHSS-4), omitting the item 'strength in the unaffected leg', in predicting stroke outcome.

Methods: The study population consisted of anterior circulation ischemic stroke patients who participated in the LUB-INT-9 trial. We included all patients in whom the following data were available: NIHSS within 6h after stroke onset and daily between days 2 and 5, and the 12-week modified Rankin Scale (mRS) score. Poor outcome was defined as a mRS score >3.

Results: There was an excellent correlation between the NIHSS and sNIHSS-4 at all time points for both left and right-sided strokes. Scores at day 2 were a good predictor of poor outcome. Cutoff scores for NIHSS and sNIHSS-4 at day 2 were 15 and 5 in left hemispheric strokes, and 12 and 4 in right hemispheric strokes.

Conclusion: The sNIHSS-4 is as good as the NIHSS at predicting stroke outcome in both right and left anterior circulation strokes. (C) 2012 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)729-731
Number of pages3
JournalClinical neurology and neurosurgery
Issue number6
Publication statusPublished - Jun-2013


  • Ischemic stroke, Stroke scales, Stroke outcome, Lateralization, ACUTE ISCHEMIC-STROKE, CLINICAL-TRIALS, SCALE, RELIABILITY, HEMISPHERE, VALIDITY

ID: 5881577