The Severity of Anaphylactic and Systemic Allergic Reactions

Pettersson, M. E., 2018, [Groningen]: University of Groningen. 141 p.

Research output: ThesisThesis fully internal (DIV)

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  • Title and contents

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  • Chapter 1

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  • Chapter 2

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  • Chapter 3

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  • Chapter 4

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  • Chapter 5

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  • Chapter 6

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  • Chapter 7

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  • Chapter 8

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  • Chapter 9

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  • Appendices

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  • Complete thesis

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  • Propositions

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This thesis provides an overview of a number of biochemical, genetic and clinical factors influencing the severity of systemic allergic and anaphylactic reactions. Special attention was given to the relationship between the eliciting dose and the severity of reaction in food allergy.
Even though there seems to be a weak relationship between the eliciting dose and the severity of DBPCFC reactions, this association is not clinically useful. Moreover, the results of this thesis shows clearly that the eliciting dose and the severity of reaction should be considered as separate factors in food allergy.
In conclusion, the severity of anaphylactic and systemic allergic reactions is multifactorial and difficult to predict. Thus, the majority of factors determining the severity of anaphylactic and systemic allergic reaction remain unknown. New factors need to be identified to allow for accurate prediction of these severe reactions.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Dubois, Anthony E.J., Supervisor
  • Koppelman, Gerard, Supervisor
  • Postma, Dirkje S., Assessment committee
  • Knulst, Andre C., Assessment committee, External person
  • Roberts, Graham, Assessment committee, External person
Award date18-Jun-2018
Place of Publication[Groningen]
Print ISBNs978-94-034-0558-2
Electronic ISBNs978-94-034-0559-9
Publication statusPublished - 2018

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