Publication

The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders

Saluja, R., Ketelaar, M. E., Hawro, T., Church, M. K., Maurer, M. & Nawijn, M. C., Jan-2015, In : Molecular Immunology. 63, 1, p. 80-85 6 p.

Research output: Contribution to journalReview articleAcademicpeer-review

Interleukin-33 (IL-33) is a recently discovered cytokine that belongs to the IL-1 superfamily and acts as an important regulator in several allergic disorders. It is considered to function as an alarmin, or danger cytokine, that is released upon structural cell damage. IL-33 activates several immune cells, including Th2 cells, mast cells and basophils, following its interaction with a cell surface heterodimer consisting of an IL-1 receptor-related protein ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP). This activation leads to the production of a variety of Th2-like cytokines that mediate allergic-type immune responses. Thus, IL-33 appears to be a double-edged sword because, in addition to its important contribution to host defence, it exacerbates allergic responses, such as allergic rhinitis and asthma. A major purported mechanism of IL-33 in allergy is the activation of mast cells to produce a variety of pro-inflammatory cytokines and chemokines. In this review, we summarize the current knowledge regarding the genetics and physiology of IL-33 and IL-1RL1 and its association with different allergic diseases by focusing on its effects on mast cells and basophils.

Original languageEnglish
Pages (from-to)80-85
Number of pages6
JournalMolecular Immunology
Volume63
Issue number1
Early online date10-Jul-2014
Publication statusPublished - Jan-2015

    Keywords

  • Mast cell, Basophil, IL-33, IL-1RL1, IL-1RAcP, Signal transduction, GENOME-WIDE ASSOCIATION, NF-KAPPA-B, CYTOKINE IL-33, SUSCEPTIBILITY LOCI, GENETIC-VARIATION, ST2 RECEPTOR, IN-VIVO, DISEASE, ASTHMA, INTERLEUKIN-33

ID: 13645177