The role of pilocarpine in the reduction of radiation induced damage to the salivary glands

Burlage, F. R., 2008, [S.n.]. 135 p.

Research output: ThesisThesis fully internal (DIV)

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Regarding late morbidity, hyposalivation is one of the most frequently reported radiation-induced side effects which has a negative impact on health-related quality of life [1;2]. Besides the subjective sensation of a dry mouth (xerostomia), saliva also plays a major role in speech, taste perception, mastication, bolus formation, swallowing, rinsing the mouth, clearing and diluting food detritus and bacterial matter, and mucosal protection [3;4]. In this thesis we investigated the role and the mechanisms of pilocarpine treatment during radiotherapy in the prevention and reduction of radiation-induced hyposalivation.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Award date11-Jun-2008
Print ISBNs9789036733809
Publication statusPublished - 2008


  • Proefschriften (vorm), Pilocarpine , Stralingsbeschadiging, Speekselklieren , Bestr, Xerostomie , Tumoren, Speeksel, neoplasmata, gezwellen, radiologie

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