Publication

The role of metabolic syndrome in late-life depression over 6 years: The NESDO study

Dekker, I. P., Marijnissen, R. M., Giltay, E. J., van der Mast, R. C., Voshaar, R. C. O., Rhebergen, D. & Ottenheim, N. R., 1-Oct-2019, In : Journal of Affective Disorders. 257, p. 735-740 6 p.

Research output: Contribution to journalArticleAcademicpeer-review

APA

Dekker, I. P., Marijnissen, R. M., Giltay, E. J., van der Mast, R. C., Voshaar, R. C. O., Rhebergen, D., & Ottenheim, N. R. (2019). The role of metabolic syndrome in late-life depression over 6 years: The NESDO study. Journal of Affective Disorders, 257, 735-740. https://doi.org/10.1016/j.jad.2019.07.060

Author

Dekker, Ilse P. ; Marijnissen, Radboud M. ; Giltay, Erik J. ; van der Mast, Roos C. ; Voshaar, Richard C. Oude ; Rhebergen, Didi ; Ottenheim, Nathaly Rius. / The role of metabolic syndrome in late-life depression over 6 years : The NESDO study. In: Journal of Affective Disorders. 2019 ; Vol. 257. pp. 735-740.

Harvard

Dekker, IP, Marijnissen, RM, Giltay, EJ, van der Mast, RC, Voshaar, RCO, Rhebergen, D & Ottenheim, NR 2019, 'The role of metabolic syndrome in late-life depression over 6 years: The NESDO study', Journal of Affective Disorders, vol. 257, pp. 735-740. https://doi.org/10.1016/j.jad.2019.07.060

Standard

The role of metabolic syndrome in late-life depression over 6 years : The NESDO study. / Dekker, Ilse P.; Marijnissen, Radboud M.; Giltay, Erik J.; van der Mast, Roos C.; Voshaar, Richard C. Oude; Rhebergen, Didi; Ottenheim, Nathaly Rius.

In: Journal of Affective Disorders, Vol. 257, 01.10.2019, p. 735-740.

Research output: Contribution to journalArticleAcademicpeer-review

Vancouver

Dekker IP, Marijnissen RM, Giltay EJ, van der Mast RC, Voshaar RCO, Rhebergen D et al. The role of metabolic syndrome in late-life depression over 6 years: The NESDO study. Journal of Affective Disorders. 2019 Oct 1;257:735-740. https://doi.org/10.1016/j.jad.2019.07.060


BibTeX

@article{05852595e0ac49adaf5c5593d80fef69,
title = "The role of metabolic syndrome in late-life depression over 6 years: The NESDO study",
abstract = "Background: Metabolic syndrome (MetS) has been associated with both early- and late-life depression. This study investigated whether baseline MetS and its individual components are associated with the course of depression over six years among older persons with a formal depression diagnosis.Methods: Data were used from 378 older persons with a depressive disorder from the Netherlands Study of Depression in Old age (NESDO) with a 6-year follow-up. A formal depression diagnosis according to DSM-IV-TR criteria was ascertained with the Composite International Diagnostic Interview. Severity of depressive symptoms was assessed with the Inventory of Depressive Symptomatology at 6-month intervals. Metabolic syndrome (MetS) was defined according the modified National Cholesterol Education Programme - Adult Treatment Panel III criteria. Primary outcome was time to remission from depression. We applied cox regression analysis for the primary outcome and linear mixed models for secondary analyses.Results: Neither MetS nor its individual components were associated with time to remission from depression (MetS: HR = 1.03; 95{\%} CI = 0.74 - 1.44; p = 0.85), or with depression severity (MetS: B = 0.02; SE = 0.04; p = 0.64) and course of depressive symptoms (MetS: B = -0.01; SE = 0.01; p = 0.23) over 6-years follow-up.Limitations: Attrition was relatively high (46.8{\%}). Furthermore, we only had information on formal depression diagnosis at baseline, 2-year, and 6-year follow-up.Conclusions: We found no evidence for an effect of baseline presence of metabolic dysregulation on the course of formally diagnosed depression in older persons. Metabolic syndrome in depressed patients should be clinically monitored for other reasons than predicting chronicity or severity of depression.",
keywords = "Metabolic syndrome, Depression, Older persons, PHYSICAL-ACTIVITY QUESTIONNAIRE, SYMPTOMATOLOGY, RELIABILITY, ASSOCIATION, INVENTORY, DISEASE, HEALTH, ADULTS",
author = "Dekker, {Ilse P.} and Marijnissen, {Radboud M.} and Giltay, {Erik J.} and {van der Mast}, {Roos C.} and Voshaar, {Richard C. Oude} and Didi Rhebergen and Ottenheim, {Nathaly Rius}",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.jad.2019.07.060",
language = "English",
volume = "257",
pages = "735--740",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "ELSEVIER SCIENCE BV",

}

RIS

TY - JOUR

T1 - The role of metabolic syndrome in late-life depression over 6 years

T2 - The NESDO study

AU - Dekker, Ilse P.

AU - Marijnissen, Radboud M.

AU - Giltay, Erik J.

AU - van der Mast, Roos C.

AU - Voshaar, Richard C. Oude

AU - Rhebergen, Didi

AU - Ottenheim, Nathaly Rius

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Metabolic syndrome (MetS) has been associated with both early- and late-life depression. This study investigated whether baseline MetS and its individual components are associated with the course of depression over six years among older persons with a formal depression diagnosis.Methods: Data were used from 378 older persons with a depressive disorder from the Netherlands Study of Depression in Old age (NESDO) with a 6-year follow-up. A formal depression diagnosis according to DSM-IV-TR criteria was ascertained with the Composite International Diagnostic Interview. Severity of depressive symptoms was assessed with the Inventory of Depressive Symptomatology at 6-month intervals. Metabolic syndrome (MetS) was defined according the modified National Cholesterol Education Programme - Adult Treatment Panel III criteria. Primary outcome was time to remission from depression. We applied cox regression analysis for the primary outcome and linear mixed models for secondary analyses.Results: Neither MetS nor its individual components were associated with time to remission from depression (MetS: HR = 1.03; 95% CI = 0.74 - 1.44; p = 0.85), or with depression severity (MetS: B = 0.02; SE = 0.04; p = 0.64) and course of depressive symptoms (MetS: B = -0.01; SE = 0.01; p = 0.23) over 6-years follow-up.Limitations: Attrition was relatively high (46.8%). Furthermore, we only had information on formal depression diagnosis at baseline, 2-year, and 6-year follow-up.Conclusions: We found no evidence for an effect of baseline presence of metabolic dysregulation on the course of formally diagnosed depression in older persons. Metabolic syndrome in depressed patients should be clinically monitored for other reasons than predicting chronicity or severity of depression.

AB - Background: Metabolic syndrome (MetS) has been associated with both early- and late-life depression. This study investigated whether baseline MetS and its individual components are associated with the course of depression over six years among older persons with a formal depression diagnosis.Methods: Data were used from 378 older persons with a depressive disorder from the Netherlands Study of Depression in Old age (NESDO) with a 6-year follow-up. A formal depression diagnosis according to DSM-IV-TR criteria was ascertained with the Composite International Diagnostic Interview. Severity of depressive symptoms was assessed with the Inventory of Depressive Symptomatology at 6-month intervals. Metabolic syndrome (MetS) was defined according the modified National Cholesterol Education Programme - Adult Treatment Panel III criteria. Primary outcome was time to remission from depression. We applied cox regression analysis for the primary outcome and linear mixed models for secondary analyses.Results: Neither MetS nor its individual components were associated with time to remission from depression (MetS: HR = 1.03; 95% CI = 0.74 - 1.44; p = 0.85), or with depression severity (MetS: B = 0.02; SE = 0.04; p = 0.64) and course of depressive symptoms (MetS: B = -0.01; SE = 0.01; p = 0.23) over 6-years follow-up.Limitations: Attrition was relatively high (46.8%). Furthermore, we only had information on formal depression diagnosis at baseline, 2-year, and 6-year follow-up.Conclusions: We found no evidence for an effect of baseline presence of metabolic dysregulation on the course of formally diagnosed depression in older persons. Metabolic syndrome in depressed patients should be clinically monitored for other reasons than predicting chronicity or severity of depression.

KW - Metabolic syndrome

KW - Depression

KW - Older persons

KW - PHYSICAL-ACTIVITY QUESTIONNAIRE

KW - SYMPTOMATOLOGY

KW - RELIABILITY

KW - ASSOCIATION

KW - INVENTORY

KW - DISEASE

KW - HEALTH

KW - ADULTS

U2 - 10.1016/j.jad.2019.07.060

DO - 10.1016/j.jad.2019.07.060

M3 - Article

VL - 257

SP - 735

EP - 740

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 97527210