Publication

The role of hydrogen sulfide in aging and age-related pathologies

Perridon, B. W., Leuvenink, H. G. D., Hillebrands, J-L., van Goor, H. & Bos, E. M., Oct-2016, In : Aging. 8, 10, p. 2264-2289 26 p.

Research output: Contribution to journalReview articleAcademicpeer-review

When humans grow older, they experience inevitable and progressive loss of physiological function, ultimately leading to death. Research on aging largely focuses on the identification of mechanisms involved in the aging process. Several proposed aging theories were recently combined as the 'hallmarks of aging'. These hallmarks describe (patho-) physiological processes that together, when disrupted, determine the aging phenotype. Sustaining evidence shows a potential role for hydrogen sulfide (H2S) in the regulation of aging.

Nowadays, H2S is acknowledged as an endogenously produced signaling molecule with various (patho-) physiological effects. H2S is involved in several diseases including pathologies related to aging. In this review, the known, assumed and hypothetical effects of hydrogen sulfide on the aging process will be discussed by reviewing its actions on the hallmarks of aging and on several age-related pathologies.

Original languageEnglish
Pages (from-to)2264-2289
Number of pages26
JournalAging
Volume8
Issue number10
Publication statusPublished - Oct-2016

    Keywords

  • hydrogen sulfide, H2S, aging, hallmarks of aging, gasotransmitters, ACTIVATED PROTEIN-KINASE, DNA-DAMAGE-RESPONSE, ONCOGENE-INDUCED SENESCENCE, HEMATOPOIETIC STEM-CELLS, NF-KAPPA-B, DEPRIVATION-INDUCED APOPTOSIS, CYSTATHIONINE BETA-SYNTHASE, VEIN ENDOTHELIAL-CELLS, LIFE-SPAN EXTENSION, OXIDATIVE STRESS

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