The Resolution of 2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-Oxide (Phencyphos) by Preferential Crystallization

Leeman, M., Querniard, F., Kaptein, B. & Kellogg, R. M., 2009, In : Organic Process Research & Development. 13, 6, p. 1379-1381 3 p.

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  • Michel Leeman
  • Florian Querniard
  • Bernard Kaptein
  • Richard M. Kellogg
An inexpensive, reliable resolution method for the resolving agent, 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was required. Anhydrous phencyphos is a racemic compound, but the hydrate is known to be a conglomerate. After examination of various solvent mixtures a preferential crystallization process in methanol/water solvent mixtures was chosen to deliver the pure enantiomers in good yields. The preferential crystallization process can be repeated up to 50 times without significant loss of efficiency.
Original languageEnglish
Pages (from-to)1379-1381
Number of pages3
JournalOrganic Process Research & Development
Issue number6
Publication statusPublished - 2009

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