The Resolution of 2-Hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-Oxide (Phencyphos) by Preferential CrystallizationLeeman, M., Querniard, F., Kaptein, B. & Kellogg, R. M., 2009, In : Organic Process Research & Development. 13, 6, p. 1379-1381 3 p.
Research output: Contribution to journal › Article › Academic
An inexpensive, reliable resolution method for the resolving agent, 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinan 2-oxide (phencyphos) was required. Anhydrous phencyphos is a racemic compound, but the hydrate is known to be a conglomerate. After examination of various solvent mixtures a preferential crystallization process in methanol/water solvent mixtures was chosen to deliver the pure enantiomers in good yields. The preferential crystallization process can be repeated up to 50 times without significant loss of efficiency.
|Number of pages||3|
|Journal||Organic Process Research & Development|
|Publication status||Published - 2009|
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