The renal angiopoietin/Tie2 system in lethal human sepsis

Aslan, A., Jongman, R. M., Moser, J., Stegeman, C. A., van Goor, H., Diepstra, A., van den Heuvel, M. C., Heeringa, P., Molema, G., Zijlstra, J. G. & van Meurs, M., 31-Mar-2014, In : Critical care (London, England). 18, 2, 3 p., 423.

Research output: Contribution to journalLetterAcademicpeer-review

Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.

Original languageEnglish
Article number423
Number of pages3
JournalCritical care (London, England)
Issue number2
Publication statusPublished - 31-Mar-2014



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