The renal angiopoietin/Tie2 system in lethal human sepsisAslan, A., Jongman, R. M., Moser, J., Stegeman, C. A., van Goor, H., Diepstra, A., van den Heuvel, M. C., Heeringa, P., Molema, G., Zijlstra, J. G. & van Meurs, M., 31-Mar-2014, In : Critical care (London, England). 18, 2, 3 p., 423.
Research output: Contribution to journal › Letter › Academic › peer-review
- Groningen Kidney Center (GKC)
- Translational Immunology Groningen (TRIGR)
- Groningen Institute for Organ Transplantation (GIOT)
- Stem Cell Aging Leukemia and Lymphoma (SALL)
- Nanobiotechnology and Advanced Therapeutic Materials (NANOBIOMAT)
- Vascular Ageing Programme (VAP)
- Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking.. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized.
|Number of pages||3|
|Journal||Critical care (London, England)|
|Publication status||Published - 31-Mar-2014|
- SHOCK, TIE2